About: Cycling of cations between T-tubular and surface membranes in a model of guinea-pig ventricular cardiomyocyte

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About: Cycling of cations between T-tubular and surface membranes in a model of guinea-pig ventricular cardiomyocyte Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The contribution of surface and t-tubular membranes to cation homeostasis was evaluated in a model of the guinea-pig ventricular myocyte with a single-compartment representation of the transverse-axial tubular system (TATS) matching detailed ultrastructural data (1), with 53% of the cell membrane in the TATS, and ionic diffusion data (2). The TATS fraction of ion transfer mechanisms was set to 0.53 (uniform distribution) except for INa and ICaL (0.64), IK1 (0.8), Na/Ca exchange (0.7) and Ca-pump (0.2). At steady-state during 4 Hz stimulation in current-clamp, 67% of Ca2+ influx occurred across the TATS membrane, while 53% of Ca2+ extrusion occurred across the surface membrane. Thus the TATS membrane mediates net Ca2+ influx, while the surface membrane mediates net Ca2+ efflux. Transient partial depletion of Ca2+ within the TATS lumen during the action potential was compensated by diffusion from the bulk external solution. The contribution of surface and t-tubular membranes to cation homeostasis was evaluated in a model of the guinea-pig ventricular myocyte with a single-compartment representation of the transverse-axial tubular system (TATS) matching detailed ultrastructural data (1), with 53% of the cell membrane in the TATS, and ionic diffusion data (2). The TATS fraction of ion transfer mechanisms was set to 0.53 (uniform distribution) except for INa and ICaL (0.64), IK1 (0.8), Na/Ca exchange (0.7) and Ca-pump (0.2). At steady-state during 4 Hz stimulation in current-clamp, 67% of Ca2+ influx occurred across the TATS membrane, while 53% of Ca2+ extrusion occurred across the surface membrane. Thus the TATS membrane mediates net Ca2+ influx, while the surface membrane mediates net Ca2+ efflux. Transient partial depletion of Ca2+ within the TATS lumen during the action potential was compensated by diffusion from the bulk external solution. (en)
Title	Cycling of cations between T-tubular and surface membranes in a model of guinea-pig ventricular cardiomyocyte Cycling of cations between T-tubular and surface membranes in a model of guinea-pig ventricular cardiomyocyte (en)
skos:prefLabel	Cycling of cations between T-tubular and surface membranes in a model of guinea-pig ventricular cardiomyocyte Cycling of cations between T-tubular and surface membranes in a model of guinea-pig ventricular cardiomyocyte (en)
skos:notation	RIV/00216224:14110/05:00014822!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021622402)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Pásek, Michal Šimurda, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	516723
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/05:00014822
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cardiac cell; tubular system; ion cycling; quantitative modelling (en)
http://linked.open.../riv/klicoveSlovo	cardiac cell tubular system ion cycling quantitative modelling
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D5DED3D9C844]
http://linked.open...i/riv/nazevZdroje	Journal of Molecular and Cellular Cardiology
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	39
http://linked.open...iv/tvurceVysledku	Orchard, Clive Pásek, Michal Šimurda, Jiří Christé, Georges
http://linked.open...ain/vavai/riv/wos	000230435000034
http://linked.open...n/vavai/riv/zamer	Early diagnostics and treatment of cardiovascular diseases
issn	0022-2828
number of pages	2 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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