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  • Formamide-induced detubulation of rat ventricular cardiac myocytes causes an ~32% decrease of membrane capacitance (Despa et al, 2003). Detailed microscopic analysis of the transverse-axial tubular system (TATS) by Soeller and Cannel (1999) showed a mean tubule diameter of 255 nm, a mean segment length of 6.87 ľm, a tubule density of 0.3 ľm-2, fractional volume of 3.6% and TATS membrane area to cell volume ratio of 0.44 ľm2/ľm3. These parameters can be approximately respected when the fraction of the total sarcolemma within the TATS is 56%. To explore possible causes for this discrepancy we used a quantitative model of the rat ventricular myocyte that included a description of TATS. Two explanations were found that could account quantitatively for the discrepancy: (i) incomplete detubulation leaving electrical access to a large area of TATS membrane, due to the branched TATS network. The estimate of Despa et al. could be met if 42% of TATS remained accessible after detubulation.
  • Formamide-induced detubulation of rat ventricular cardiac myocytes causes an ~32% decrease of membrane capacitance (Despa et al, 2003). Detailed microscopic analysis of the transverse-axial tubular system (TATS) by Soeller and Cannel (1999) showed a mean tubule diameter of 255 nm, a mean segment length of 6.87 ľm, a tubule density of 0.3 ľm-2, fractional volume of 3.6% and TATS membrane area to cell volume ratio of 0.44 ľm2/ľm3. These parameters can be approximately respected when the fraction of the total sarcolemma within the TATS is 56%. To explore possible causes for this discrepancy we used a quantitative model of the rat ventricular myocyte that included a description of TATS. Two explanations were found that could account quantitatively for the discrepancy: (i) incomplete detubulation leaving electrical access to a large area of TATS membrane, due to the branched TATS network. The estimate of Despa et al. could be met if 42% of TATS remained accessible after detubulation. (en)
Title
  • Quantitative exploration of T-tubular membrane parameters in a model of rat ventricular cardiomyocyte
  • Quantitative exploration of T-tubular membrane parameters in a model of rat ventricular cardiomyocyte (en)
skos:prefLabel
  • Quantitative exploration of T-tubular membrane parameters in a model of rat ventricular cardiomyocyte
  • Quantitative exploration of T-tubular membrane parameters in a model of rat ventricular cardiomyocyte (en)
skos:notation
  • RIV/00216224:14110/05:00014820!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM0021622402)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 539832
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/05:00014820
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • cardiac cell; tubular system; quantitative modelling (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [E3B7791502B5]
http://linked.open...i/riv/nazevZdroje
  • Journal of Molecular and Cellular Cardiology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 39
http://linked.open...iv/tvurceVysledku
  • Orchard, Clive
  • Pásek, Michal
  • Šimurda, Jiří
  • Christé, Georges
http://linked.open...ain/vavai/riv/wos
  • 000230435000042
http://linked.open...n/vavai/riv/zamer
issn
  • 0022-2828
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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