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Description
  • Kanabidiol je bioprekurzor tetrahydrokanabinolu (THC) bez psychotomimetických účinků. V literatuře se uvádí jeho potenciální antikonvulsivní, antipsychotické, antidepresivní, antiemetické a protizánětlivé působení. V naší studii jsme s použitím modelu opakovaných párových interakcí dospělých myších samců hodnotili potenciálně antidepresivní behaviorální účinky kanabidiolu. Naše výsledky v souladu s humánními studiemi naznačují anxiolytické, případně antidepresivní působení kanabidiolu. (cs)
  • Cannabidiol, a nonpsychotropic cannabis constituent, with potential anticonvulsive, antianxiety, antipsychotic, antiemetic, and anti-inflammatory properties (Mechoulam et al., 2002) was tested for its behavioural effects in the mouse model of social defeat using a naturally occurring intra-species social conflict situation. The present study investigated effects of cannabidiol on locomotor behavioural changes in the open field in non-aggressive group-housed male mice which served several times as opponents to aggressive singly-housed mice. The results suggest a potential anxiolytic effect of cannabidiol in mice defeated by an aggressive conspecific partner.
  • Cannabidiol, a nonpsychotropic cannabis constituent, with potential anticonvulsive, antianxiety, antipsychotic, antiemetic, and anti-inflammatory properties (Mechoulam et al., 2002) was tested for its behavioural effects in the mouse model of social defeat using a naturally occurring intra-species social conflict situation. The present study investigated effects of cannabidiol on locomotor behavioural changes in the open field in non-aggressive group-housed male mice which served several times as opponents to aggressive singly-housed mice. The results suggest a potential anxiolytic effect of cannabidiol in mice defeated by an aggressive conspecific partner. (en)
Title
  • Effect of cannabidiol on behavioural changes elicited by social defeat in mice
  • Účinky kanabidiolu na změny chování vyvolané sociální porážkou u myší (cs)
  • Effect of cannabidiol on behavioural changes elicited by social defeat in mice (en)
skos:prefLabel
  • Effect of cannabidiol on behavioural changes elicited by social defeat in mice
  • Účinky kanabidiolu na změny chování vyvolané sociální porážkou u myší (cs)
  • Effect of cannabidiol on behavioural changes elicited by social defeat in mice (en)
skos:notation
  • RIV/00216224:14110/05:00014434!RIV09-MSM-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM0021622404)
http://linked.open...iv/cisloPeriodika
  • Suppl.3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 519252
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/05:00014434
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • cannabidiol; social defeat; mice; antidepressant; animal model (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [6935FF3BDA28]
http://linked.open...i/riv/nazevZdroje
  • European Neuropsychopharmacology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 15
http://linked.open...iv/tvurceVysledku
  • Šulcová, Alexandra
  • Pistovčáková, Jana
http://linked.open...ain/vavai/riv/wos
  • 000233860601132
http://linked.open...n/vavai/riv/zamer
issn
  • 0924-977X
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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