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  • Ajmaline decreased the upstroke velocity of action potential and action potential amplitude, increased the action potential duration measured at 50 and 90% repolarization, and reversibly inhibited most components of membrane ionic current in a concentration-dependent manner; IC50 was 27.8 umol/l for INa, 70.8 umol/l for ICa, 25.9 umol/l for Ito, 61.0 umol/l for IK, and 13.3 umol/l for IKATP.
  • Ajmaline decreased the upstroke velocity of action potential and action potential amplitude, increased the action potential duration measured at 50 and 90% repolarization, and reversibly inhibited most components of membrane ionic current in a concentration-dependent manner; IC50 was 27.8 umol/l for INa, 70.8 umol/l for ICa, 25.9 umol/l for Ito, 61.0 umol/l for IK, and 13.3 umol/l for IKATP. (en)
Title
  • Effect of ajmaline on action potential and ionic currents in rat ventricular myocytes
  • Effect of ajmaline on action potential and ionic currents in rat ventricular myocytes (en)
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  • Effect of ajmaline on action potential and ionic currents in rat ventricular myocytes
  • Effect of ajmaline on action potential and ionic currents in rat ventricular myocytes (en)
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  • RIV/00216224:14110/05:00014397!RIV10-MSM-14110___
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  • 519233
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  • RIV/00216224:14110/05:00014397
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  • ajmaline; action potential; ionic currents; concentration dependence; rat ventricular myocytes (en)
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  • CZ - Česká republika
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  • [25C0B8FC72EB]
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  • General Physiology and Biophysics
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  • 24
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  • Bébarová, Markéta
  • Pásek, Michal
  • Šimurda, Jiří
  • Šimurdová, Milena
  • Matejovič, Peter
http://linked.open...ain/vavai/riv/wos
  • 000233582900004
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  • 0231-5882
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  • 14110
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