About: Effect of St John's wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver

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About: Effect of St John's wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	St. John's wort (Hypericum perforatum) is a popular over-the-counter dietary supplement and a herbal antidepressant that has been implicated in drug interactions with substrates of several cytochrome P-450 (CYP) isozymes. The effects of the St. John's wort extract (100 mg/kg, i.p., once daily for 10 days) on metabolic activity of CYP450 were assessed in the system of isolated perfused rat liver. The substrates used in this study were tolbutamide (CYP2C6), dextromethorphan (CYP2D2) and midazolam (CYP3A2). Validated HPLC method was used to quantify all compounds of interest. St. John's wort administration affected CYP activity, causing a significant decline in AUC of dextromethorphan [F(4,31) = 1511, p < 0.001; PLSD, p < 0.001] and AUC of midazolam [F(3,25) = 221, p < 0.001; PLSD, p = 0.035] and a significant increase in AUC of tolbutamide [F(3,26) = 200, p < 0.001; PLSD, p < 0.001]. St. St. John's wort (Hypericum perforatum) is a popular over-the-counter dietary supplement and a herbal antidepressant that has been implicated in drug interactions with substrates of several cytochrome P-450 (CYP) isozymes. The effects of the St. John's wort extract (100 mg/kg, i.p., once daily for 10 days) on metabolic activity of CYP450 were assessed in the system of isolated perfused rat liver. The substrates used in this study were tolbutamide (CYP2C6), dextromethorphan (CYP2D2) and midazolam (CYP3A2). Validated HPLC method was used to quantify all compounds of interest. St. John's wort administration affected CYP activity, causing a significant decline in AUC of dextromethorphan [F(4,31) = 1511, p < 0.001; PLSD, p < 0.001] and AUC of midazolam [F(3,25) = 221, p < 0.001; PLSD, p = 0.035] and a significant increase in AUC of tolbutamide [F(3,26) = 200, p < 0.001; PLSD, p < 0.001]. St. (en)
Title	Effect of St John's wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver Effect of St John's wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver (en)
skos:prefLabel	Effect of St John's wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver Effect of St John's wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver (en)
skos:notation	RIV/00216224:14110/05:00014108!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 141100001), Z(MSM6046137301)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Pistovčáková, Jana Juřica, Jan Šulcová, Alexandra Tomandl, Josef McCaskey Hadašová, Eva Dostálek, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	519445
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/05:00014108
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	St John's wort; cytochrome P450; perfused rat liver; drug interaction (en)
http://linked.open.../riv/klicoveSlovo	drug interaction perfused rat liver cytochrome P450 St John's wort
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[8FA54F702E88]
http://linked.open...i/riv/nazevZdroje	Life Sciences
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	78
http://linked.open...iv/tvurceVysledku	Dostálek, Miroslav Juřica, Jan Tomandl, Josef Šulcová, Alexandra Linhart, Igor Pistovčáková, Jana McCaskey Hadašová, Eva
http://linked.open...ain/vavai/riv/wos	000233330000003
http://linked.open...n/vavai/riv/zamer	Catalytic processes in chemistry and chemical technology http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20141100001
issn	0024-3205
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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