Attributes | Values |
---|
rdf:type
| |
Description
| - St. John's wort (Hypericum perforatum) is a popular over-the-counter dietary supplement and a herbal antidepressant that has been implicated in drug interactions with substrates of several cytochrome P-450 (CYP) isozymes. The effects of the St. John's wort extract (100 mg/kg, i.p., once daily for 10 days) on metabolic activity of CYP450 were assessed in the system of isolated perfused rat liver. The substrates used in this study were tolbutamide (CYP2C6), dextromethorphan (CYP2D2) and midazolam (CYP3A2). Validated HPLC method was used to quantify all compounds of interest. St. John's wort administration affected CYP activity, causing a significant decline in AUC of dextromethorphan [F(4,31) = 1511, p < 0.001; PLSD, p < 0.001] and AUC of midazolam [F(3,25) = 221, p < 0.001; PLSD, p = 0.035] and a significant increase in AUC of tolbutamide [F(3,26) = 200, p < 0.001; PLSD, p < 0.001]. St.
- St. John's wort (Hypericum perforatum) is a popular over-the-counter dietary supplement and a herbal antidepressant that has been implicated in drug interactions with substrates of several cytochrome P-450 (CYP) isozymes. The effects of the St. John's wort extract (100 mg/kg, i.p., once daily for 10 days) on metabolic activity of CYP450 were assessed in the system of isolated perfused rat liver. The substrates used in this study were tolbutamide (CYP2C6), dextromethorphan (CYP2D2) and midazolam (CYP3A2). Validated HPLC method was used to quantify all compounds of interest. St. John's wort administration affected CYP activity, causing a significant decline in AUC of dextromethorphan [F(4,31) = 1511, p < 0.001; PLSD, p < 0.001] and AUC of midazolam [F(3,25) = 221, p < 0.001; PLSD, p = 0.035] and a significant increase in AUC of tolbutamide [F(3,26) = 200, p < 0.001; PLSD, p < 0.001]. St. (en)
|
Title
| - Effect of St John's wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver
- Effect of St John's wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver (en)
|
skos:prefLabel
| - Effect of St John's wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver
- Effect of St John's wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver (en)
|
skos:notation
| - RIV/00216224:14110/05:00014108!RIV10-MSM-14110___
|
http://linked.open...avai/riv/aktivita
| |
http://linked.open...avai/riv/aktivity
| - Z(MSM 141100001), Z(MSM6046137301)
|
http://linked.open...iv/cisloPeriodika
| |
http://linked.open...vai/riv/dodaniDat
| |
http://linked.open...aciTvurceVysledku
| |
http://linked.open.../riv/druhVysledku
| |
http://linked.open...iv/duvernostUdaju
| |
http://linked.open...titaPredkladatele
| |
http://linked.open...dnocenehoVysledku
| |
http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/05:00014108
|
http://linked.open...riv/jazykVysledku
| |
http://linked.open.../riv/klicovaSlova
| - St John's wort; cytochrome P450; perfused rat liver; drug interaction (en)
|
http://linked.open.../riv/klicoveSlovo
| |
http://linked.open...odStatuVydavatele
| |
http://linked.open...ontrolniKodProRIV
| |
http://linked.open...i/riv/nazevZdroje
| |
http://linked.open...in/vavai/riv/obor
| |
http://linked.open...ichTvurcuVysledku
| |
http://linked.open...cetTvurcuVysledku
| |
http://linked.open...UplatneniVysledku
| |
http://linked.open...v/svazekPeriodika
| |
http://linked.open...iv/tvurceVysledku
| - Dostálek, Miroslav
- Juřica, Jan
- Tomandl, Josef
- Šulcová, Alexandra
- Linhart, Igor
- Pistovčáková, Jana
- McCaskey Hadašová, Eva
|
http://linked.open...ain/vavai/riv/wos
| |
http://linked.open...n/vavai/riv/zamer
| |
issn
| |
number of pages
| |
http://localhost/t...ganizacniJednotka
| |