About: Effect of acute and sub-chronic administration of methamphetamine on activity of CYP2D in isolated perfused rat liver.

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About: Effect of acute and sub-chronic administration of methamphetamine on activity of CYP2D in isolated perfused rat liver. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	---------------------------------- (cs) The aim of this study was to ascertain the influence of acute and repeated methamphetamine administration on metabolic activity of CYP2D2. The study was performed in the model of isolated perfused rat liver using dextromethorphan as a specific marker of CYP2D2 activity. Acute administration of methamphetamine (10, 20 or 40 mg/kg, i.p., once daily for two days) significantly increased dextrorphan O-formation in the isolated liver mediated by CYP2D2 at all investigated doses in the 120th min of liver perfusion. Repeated administration of methamphetamine (10, 20 or 40 mg/kg, i.p., once daily for six days) significantly stimulated dextromethorphan O-demethylation via CYP2D2 dose-dependently. Thus, an induction of CYP2D2 metabolic activity was proved in these experiments. With regard to a high level of homology between human and rat CYP isoform studied, the results may have clinical impact in pharmacotherapy of methamphetamine abusers. The aim of this study was to ascertain the influence of acute and repeated methamphetamine administration on metabolic activity of CYP2D2. The study was performed in the model of isolated perfused rat liver using dextromethorphan as a specific marker of CYP2D2 activity. Acute administration of methamphetamine (10, 20 or 40 mg/kg, i.p., once daily for two days) significantly increased dextrorphan O-formation in the isolated liver mediated by CYP2D2 at all investigated doses in the 120th min of liver perfusion. Repeated administration of methamphetamine (10, 20 or 40 mg/kg, i.p., once daily for six days) significantly stimulated dextromethorphan O-demethylation via CYP2D2 dose-dependently. Thus, an induction of CYP2D2 metabolic activity was proved in these experiments. With regard to a high level of homology between human and rat CYP isoform studied, the results may have clinical impact in pharmacotherapy of methamphetamine abusers. (en)
Title	Effect of acute and sub-chronic administration of methamphetamine on activity of CYP2D in isolated perfused rat liver. Vliv akutního a opakovaného podávání metamfetaminu na aktivitu CYP2D na modelu izolovaných perfundovaných jater (cs) Effect of acute and sub-chronic administration of methamphetamine on activity of CYP2D in isolated perfused rat liver. (en)
skos:prefLabel	Effect of acute and sub-chronic administration of methamphetamine on activity of CYP2D in isolated perfused rat liver. Vliv akutního a opakovaného podávání metamfetaminu na aktivitu CYP2D na modelu izolovaných perfundovaných jater (cs) Effect of acute and sub-chronic administration of methamphetamine on activity of CYP2D in isolated perfused rat liver. (en)
skos:notation	RIV/00216224:14110/05:00014068!RIV08-MSM-14110___
http://linked.open.../vavai/riv/strany	339-345
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 141100001)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Minaříková, Veronika Pistovčáková, Jana Juřica, Jan Tomandl, Josef McCaskey Hadašová, Eva Dostálek, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	519224
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/05:00014068
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Methamphetamine; Dextromethorphan; CYP2D; Liver; isolated perfused; Rat (en)
http://linked.open.../riv/klicoveSlovo	CYP2D Liver isolated perfused Methamphetamine Rat Dextromethorphan
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[3F94DE9C3F95]
http://linked.open...i/riv/nazevZdroje	Acta Veterinaria Brno
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	74
http://linked.open...iv/tvurceVysledku	Dostálek, Miroslav Juřica, Jan Tomandl, Josef Pistovčáková, Jana McCaskey Hadašová, Eva Minaříková, Veronika
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20141100001
issn	0001-7213
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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