| Attributes | Values |
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| rdf:type
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| Description
| - Qvarterní benzo[c]phenanthridinové alkaloidy (QBA) jsou skupinou přírodních produktů, které jsou v současnosti diskutovány jako potenciální cytostatika. Vyskytují se v rostlinách čeledí Papaveraceae, Fumariaceae a Rutaceae. Nejznámější a nejlépe prostudované jsou Sanguinarin and chelerytrin, informace o biologických aktivitách minoritních derivátů jsou vzácné. Tato studie se zabývá srovnáním antiproliferační aktivity sanguinarinu (SA), chelerythrinu (CHE) a minoritních derivátů sanguirubine (SR), chelirubine (CHR) and macarpinu (MA) na linii normálních lidských kožních fibroblastů a 3 nádorové buněčné linie (HeLa; A 431; HL-60). Antiproliferační aktivita byla stanovena po 72 hodinové kultivaci pomocí MTT assae, schopnost indukovat apoptózu byla studována pomocí kombinace Anexinu V-FITC a propidium jodidu a hodnocena kvantitastivne průtokovou cytometrií. (cs)
- Quaternary benzo[c]phenanthridine alkaloids (QBA) are group of natural products, which are discussed as potencial cytostatics for cancer treatment. QBA are relatively small group of isoquinoline alkaloids that have phenylalanin as their precursor. They are distributed in a number of plant species of Papaveraceae, Fumariaceae and Rutaceae families. Sanguinarin and chelerythrin are the two best known QBA and their biological activities have been widely studied (1,2,3). In addition to them about 10 other QBA differing only by substitution on the aromatic rings have been isolated as a minor components. The informations about biological effects of this minor QBA are rare. In this study the differential cytotoxicity of sanguinarine (SA), chelerythrine (CHE) and their minority derivates sanguirubine (SR), chelirubine (CHR) and macarpine (MA) was assessed in vitro by MTT assay. One normal (skin fibroblasts) and 3 tumour cell lines (HeLa; A 431; HL-60) were used as a model object. After 72 hours, MT
- Quaternary benzo[c]phenanthridine alkaloids (QBA) are group of natural products, which are discussed as potencial cytostatics for cancer treatment. QBA are relatively small group of isoquinoline alkaloids that have phenylalanin as their precursor. They are distributed in a number of plant species of Papaveraceae, Fumariaceae and Rutaceae families. Sanguinarin and chelerythrin are the two best known QBA and their biological activities have been widely studied (1,2,3). In addition to them about 10 other QBA differing only by substitution on the aromatic rings have been isolated as a minor components. The informations about biological effects of this minor QBA are rare. In this study the differential cytotoxicity of sanguinarine (SA), chelerythrine (CHE) and their minority derivates sanguirubine (SR), chelirubine (CHR) and macarpine (MA) was assessed in vitro by MTT assay. One normal (skin fibroblasts) and 3 tumour cell lines (HeLa; A 431; HL-60) were used as a model object. After 72 hours, MT (en)
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| Title
| - Biological effects of benzo[c]phenanthridine alkaloids.
- Biologické aktivity benzo[c]phenanthridinových alkaloidů (cs)
- Biological effects of benzo[c]phenanthridine alkaloids. (en)
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| skos:prefLabel
| - Biological effects of benzo[c]phenanthridine alkaloids.
- Biologické aktivity benzo[c]phenanthridinových alkaloidů (cs)
- Biological effects of benzo[c]phenanthridine alkaloids. (en)
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| skos:notation
| - RIV/00216224:14110/05:00013264!RIV06-MSM-14110___
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GA525/04/0017), P(GD301/03/H005), Z(MSM0021622415)
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| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/05:00013264
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - benzo[c]phenanthridine alkaloids; apoptosis; cytotoxicity; MTT assay (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Journal of Applied Biomedicine
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Slaninová, Iva
- Táborská, Eva
- Slunská, Zdenka
- Sinkora, Jiří
- Vlkova, Marcela
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| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
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| http://localhost/t...ganizacniJednotka
| |
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