About: Molecular recognition of colicin U and Y pore-forming domains by their cognate immunity proteins.

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About: Molecular recognition of colicin U and Y pore-forming domains by their cognate immunity proteins. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Colicin U is an antibacterial pore-forming toxin produced by Shigella boydii that kills sensitive bacterial strains of Escherichia coli and closely related organisms [1]. The colicin U transmembrane immunity protein [2] that is encoded on the pColU plasmid ensures that producer bacteria are protected against the colicin U lethal action. The colicin-immunity protein recognition is a suitable model for studying protein-protein interactions. More than 40 mutant colicins were prepared and their toxic effect was tested on the sensitive bacteria transformed with plasmid harboring either cui (colicin U immunity) gene or cyi (colicin Y immunity) gene. Colicin U variants with point mutations in the hydrophobic hairpin, F576Y and G580V, were significantly less recognized by Cui, in addition to colicin U with K609R mutation localized downstream of hydrophobic hairpin. Colicin U is an antibacterial pore-forming toxin produced by Shigella boydii that kills sensitive bacterial strains of Escherichia coli and closely related organisms [1]. The colicin U transmembrane immunity protein [2] that is encoded on the pColU plasmid ensures that producer bacteria are protected against the colicin U lethal action. The colicin-immunity protein recognition is a suitable model for studying protein-protein interactions. More than 40 mutant colicins were prepared and their toxic effect was tested on the sensitive bacteria transformed with plasmid harboring either cui (colicin U immunity) gene or cyi (colicin Y immunity) gene. Colicin U variants with point mutations in the hydrophobic hairpin, F576Y and G580V, were significantly less recognized by Cui, in addition to colicin U with K609R mutation localized downstream of hydrophobic hairpin. (en)
Title	Molecular recognition of colicin U and Y pore-forming domains by their cognate immunity proteins. Molecular recognition of colicin U and Y pore-forming domains by their cognate immunity proteins. (en)
skos:prefLabel	Molecular recognition of colicin U and Y pore-forming domains by their cognate immunity proteins. Molecular recognition of colicin U and Y pore-forming domains by their cognate immunity proteins. (en)
skos:notation	RIV/00216224:14110/05:00013203!RIV10-GA0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA310/03/1091), Z(MSM0021622415)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Šmarda, Jan Šmajs, David Doležalová, Magda
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	531021
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/05:00013203
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	colicin U; colicin Y; immunity protein (en)
http://linked.open.../riv/klicoveSlovo	colicin U colicin Y immunity protein
http://linked.open...ontrolniKodProRIV	[41792B899B02]
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Mapping of the colicin route to the sensitive and immune bacterium: studies on colicin-receptor and colicin-immunity protein interaction
http://linked.open...UplatneniVysledku	2005
http://linked.open...iv/tvurceVysledku	Šmarda, Jan Šmajs, David Janalíková, Magda
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
http://localhost/t...ganizacniJednotka	14110

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