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  • The main determinants of rate-dependent of action potential duration in rat ventricular myocytes are variations of the L-type calcium current ICa-L (gradual increase caused by modulatory effect of the Ca2+ transient) and the transient outward current Ito (decrease due to cumulative inactivation). These contemporary variations of ICa-L and Ito supported each other in the rate-dependent modulation of action potential prolongation. Under our experimental conditions, participation of other currents was negligible.
  • The main determinants of rate-dependent of action potential duration in rat ventricular myocytes are variations of the L-type calcium current ICa-L (gradual increase caused by modulatory effect of the Ca2+ transient) and the transient outward current Ito (decrease due to cumulative inactivation). These contemporary variations of ICa-L and Ito supported each other in the rate-dependent modulation of action potential prolongation. Under our experimental conditions, participation of other currents was negligible. (en)
Title
  • Action potential voltage clamp analysis of rate-dependent changes of action potential in rat ventricular myocytes
  • Action potential voltage clamp analysis of rate-dependent changes of action potential in rat ventricular myocytes (en)
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  • Action potential voltage clamp analysis of rate-dependent changes of action potential in rat ventricular myocytes
  • Action potential voltage clamp analysis of rate-dependent changes of action potential in rat ventricular myocytes (en)
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  • RIV/00216224:14110/05:00013081!RIV11-GA0-14110___
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  • P(GA305/04/1385), Z(MSM 141100004)
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  • 511292
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  • RIV/00216224:14110/05:00013081
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  • action potential; AP clamp; rate dependence; rat (en)
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  • [8758D01D472C]
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  • Bébarová, Markéta
  • Pásek, Michal
  • Šimurda, Jiří
  • Šimurdová, Milena
  • Matejovič, Peter
http://linked.open...n/vavai/riv/zamer
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  • 14110
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