About: A polymorphism in exon of the CD14 gene and atopic phenotypes in Czech young patients with IgE-mediated allergy     Goto   Sponge   NotDistinct   Permalink

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Description
  • Gen kódující CD14 receptor je kandidátním genem pro atopii vzhledem ke své poloze na chromozomu 5q. V této studii byla nalezena asociace 1341G/T polymorfizmu v CD14 genu s atopickým fenotypem v české populaci. (cs)
  • Atopy is a generally considered to be caused by interaction of genetic and environmental factors. The gene encoding CD14 is a positional candidate gene for atopy, as it is localized on chromosome 5q31.1, a region that has been linked to asthma and atopic responses. We investigated relationship among atopic phenotypes and the 1341G/T polymorphism in exon of the CD14 gene in the Czech population. Polymerase chain reaction with RFLP analyses were used to determine the CD14 genotypes in subjects with IgE-mediated allergic diseases (n = 290) and random controls (n = 189). IgE-mediated allergy was recognised by specific IgE or a positive skin prick test to any one or more allergens. The CD14 allele or genotype distributions were similar in patients and control group. However, when atopic patients were subdivided in subjects with positive and those with negative skin prick tests, this polymorphism was significantly associated with a positive reactivity to the mites. T allele of the 1341G/T polymorphism were
  • Atopy is a generally considered to be caused by interaction of genetic and environmental factors. The gene encoding CD14 is a positional candidate gene for atopy, as it is localized on chromosome 5q31.1, a region that has been linked to asthma and atopic responses. We investigated relationship among atopic phenotypes and the 1341G/T polymorphism in exon of the CD14 gene in the Czech population. Polymerase chain reaction with RFLP analyses were used to determine the CD14 genotypes in subjects with IgE-mediated allergic diseases (n = 290) and random controls (n = 189). IgE-mediated allergy was recognised by specific IgE or a positive skin prick test to any one or more allergens. The CD14 allele or genotype distributions were similar in patients and control group. However, when atopic patients were subdivided in subjects with positive and those with negative skin prick tests, this polymorphism was significantly associated with a positive reactivity to the mites. T allele of the 1341G/T polymorphism were (en)
Title
  • A polymorphism in exon of the CD14 gene and atopic phenotypes in Czech young patients with IgE-mediated allergy
  • A polymorphism in exon of the CD14 gene and atopic phenotypes in Czech young patients with IgE-mediated allergy (en)
  • Polymorfizmus v exonu genu pro CD14 receptor u mladých atopických pacientů v české populaci (cs)
skos:prefLabel
  • A polymorphism in exon of the CD14 gene and atopic phenotypes in Czech young patients with IgE-mediated allergy
  • A polymorphism in exon of the CD14 gene and atopic phenotypes in Czech young patients with IgE-mediated allergy (en)
  • Polymorfizmus v exonu genu pro CD14 receptor u mladých atopických pacientů v české populaci (cs)
skos:notation
  • RIV/00216224:14110/05:00012716!RIV06-GA0-14110___
http://linked.open.../vavai/riv/strany
  • 74-74
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GP310/03/D193)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 511026
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/05:00012716
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • CD14; gene; polymorphism; IgE; allergy (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [26FD4878BE49]
http://linked.open...v/mistoKonaniAkce
  • Athens, Greece
http://linked.open...i/riv/mistoVydani
  • Moscow, Russia
http://linked.open...i/riv/nazevZdroje
  • International Journal on Immunorehabilitation
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Izakovičová-Hollá, Lydie
  • Bučková, Dana
  • Znojil, Vladimír
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
issn
  • 1562-3629
number of pages
http://purl.org/ne...btex#hasPublisher
  • III European Asthma Congress
http://localhost/t...ganizacniJednotka
  • 14110
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