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  • The mechanism of ajmaline-induced inhibition of the transient outward current Ito has been investigated in right ventricular myocytes of rat using the whole cell patch clamp technique. Ajmaline decreased the amplitude and the time integral of Ito in a concentration-dependent, but frequency- and use-independent manner. We conclude that in the rat right ventricular myocytes ajmaline is an open channel blocker of Ito with fast recovery from the block at resting voltage.
  • The mechanism of ajmaline-induced inhibition of the transient outward current Ito has been investigated in right ventricular myocytes of rat using the whole cell patch clamp technique. Ajmaline decreased the amplitude and the time integral of Ito in a concentration-dependent, but frequency- and use-independent manner. We conclude that in the rat right ventricular myocytes ajmaline is an open channel blocker of Ito with fast recovery from the block at resting voltage. (en)
Title
  • Effect of ajmaline on transient outward current Ito in rat ventricular myocytes
  • Effect of ajmaline on transient outward current Ito in rat ventricular myocytes (en)
skos:prefLabel
  • Effect of ajmaline on transient outward current Ito in rat ventricular myocytes
  • Effect of ajmaline on transient outward current Ito in rat ventricular myocytes (en)
skos:notation
  • RIV/00216224:14110/05:00012351!RIV10-GA0-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GP204/02/D129), Z(MSM 141100004), Z(MSM0021622402)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...dnocenehoVysledku
  • 519236
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/05:00012351
http://linked.open...riv/jazykVysledku
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  • ajmaline; transient outward current; rat; frequency dependence (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • SK - Slovenská republika
http://linked.open...ontrolniKodProRIV
  • [4C912C67B723]
http://linked.open...i/riv/nazevZdroje
  • General Physiology and Biophysics
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...v/svazekPeriodika
  • 24
http://linked.open...iv/tvurceVysledku
  • Bébarová, Markéta
  • Pásek, Michal
  • Šimurda, Jiří
  • Šimurdová, Milena
  • Matejovič, Peter
http://linked.open...ain/vavai/riv/wos
  • 000229261400003
http://linked.open...n/vavai/riv/zamer
issn
  • 0231-5882
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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