About: Efficacy of newly synthesized 44Bu ultrashort-acting beta-adrenergic antagonist to isoprenaline-induced tachycardia

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About: Efficacy of newly synthesized 44Bu ultrashort-acting beta-adrenergic antagonist to isoprenaline-induced tachycardia - comparison with esmolol Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of this study was testing of the action of three newly synthesized potential ultrashort acting beta-blockers on heart rate in rat. Bradycardic effect of the compound 44Bu was compared with the action of esmolol. The effects of 44Bu and esmolol were not different in the onset, but in the depth of heart rate decrease, above all at higher concentrations. We conclude that the ultrashort beta adrenergic blocking properties of 44Bu were verified. The aim of this study was testing of the action of three newly synthesized potential ultrashort acting beta-blockers on heart rate in rat. Bradycardic effect of the compound 44Bu was compared with the action of esmolol. The effects of 44Bu and esmolol were not different in the onset, but in the depth of heart rate decrease, above all at higher concentrations. We conclude that the ultrashort beta adrenergic blocking properties of 44Bu were verified. (en)
Title	Efficacy of newly synthesized 44Bu ultrashort-acting beta-adrenergic antagonist to isoprenaline-induced tachycardia - comparison with esmolol Efficacy of newly synthesized 44Bu ultrashort-acting beta-adrenergic antagonist to isoprenaline-induced tachycardia - comparison with esmolol (en)
skos:prefLabel	Efficacy of newly synthesized 44Bu ultrashort-acting beta-adrenergic antagonist to isoprenaline-induced tachycardia - comparison with esmolol Efficacy of newly synthesized 44Bu ultrashort-acting beta-adrenergic antagonist to isoprenaline-induced tachycardia - comparison with esmolol (en)
skos:notation	RIV/00216224:14110/04:00030817!RIV10-MSM-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NL7455), Z(MSM 161700002), Z(MSM 163700003)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Bébarová, Markéta Frydrych, Marek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	562215
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/04:00030817
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	beta-blocker; isoprenaline; tachycardia; esmolol; ionic currents; rat (en)
http://linked.open.../riv/klicoveSlovo	isoprenaline tachycardia beta-blocker rat esmolol ionic currents
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[C4200BBA02CF]
http://linked.open...i/riv/nazevZdroje	Acta Veterinaria Brunensis
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Monitoring of the Dependence of Effect on Dose and of Basic Pharmacokinetic Parameters in Original Substances with Antioxidative Effect
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	73
http://linked.open...iv/tvurceVysledku	Bébarová, Markéta Bartošová, L. Mokrý, P. Beránková, K. Frydrych, Marek Brunclík, V. Kolevská, J. Huláková, G. Strnadová, V.
http://linked.open...ain/vavai/riv/wos	000223216200003
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20161700002 http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20163700003
issn	0001-7213
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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