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Description
| - To explore the possible role of t-tubular system in the physiological modulation of cardiac electrical and contractile activity, we designed mathematical models of guinea pig and rat ventricular cardiomyocytes in which the t-tubules were described as a single compartment. In both models, action potential responses to brief stimulations in current clamp are accompanied by transient K+ accumulation and transient Ca2+ depletion in the t-tubule lumen. The amplitude of these changes, relative to external ion concentrations, was studied at steady state at frequencies of 1 to 5 Hz. In the rat model, Ca2+ depletion increased from 11.8 % to 20.8 % with stimulation frequency. Meanwhile, K+ accumulation decreased from 4.3 % to 3 %. On the contrary, the guinea pig model exhibited decrease of tubular Ca2+ depletion from 15.6 % to 7.1 % and increase of tubular K+ accumulation from 2.5 % to 3.4 % in the same frequency range.
- To explore the possible role of t-tubular system in the physiological modulation of cardiac electrical and contractile activity, we designed mathematical models of guinea pig and rat ventricular cardiomyocytes in which the t-tubules were described as a single compartment. In both models, action potential responses to brief stimulations in current clamp are accompanied by transient K+ accumulation and transient Ca2+ depletion in the t-tubule lumen. The amplitude of these changes, relative to external ion concentrations, was studied at steady state at frequencies of 1 to 5 Hz. In the rat model, Ca2+ depletion increased from 11.8 % to 20.8 % with stimulation frequency. Meanwhile, K+ accumulation decreased from 4.3 % to 3 %. On the contrary, the guinea pig model exhibited decrease of tubular Ca2+ depletion from 15.6 % to 7.1 % and increase of tubular K+ accumulation from 2.5 % to 3.4 % in the same frequency range. (en)
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Title
| - Concentration changes in Ca2+ and K+ in the t-tubules of rat and guinea pig as estimated in two models of ventricular myocytes
- Concentration changes in Ca2+ and K+ in the t-tubules of rat and guinea pig as estimated in two models of ventricular myocytes (en)
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skos:prefLabel
| - Concentration changes in Ca2+ and K+ in the t-tubules of rat and guinea pig as estimated in two models of ventricular myocytes
- Concentration changes in Ca2+ and K+ in the t-tubules of rat and guinea pig as estimated in two models of ventricular myocytes (en)
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skos:notation
| - RIV/00216224:14110/04:00028362!RIV10-AV0-14110___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/04:00028362
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - cardiac cell; tubular system; quantitative modelling (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Orchard, Clive
- Pásek, Michal
- Šimurda, Jiří
- Christé, Georges
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http://linked.open...n/vavai/riv/zamer
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http://localhost/t...ganizacniJednotka
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