About: Changes of [Ca2+] in the t-tubule lumen during activity may modulate the inotropic state of rat cardiac ventricular myocytes     Goto   Sponge   NotDistinct   Permalink

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Description
  • The majority of trans-sarcolemmal Ca2+ flux occurs across the t-tubule membrane, which therefore plays a key role in cardiac excitation-contraction coupling; however Ca2+ within the t-tubules does not equilibrate instantaneously with the bulk extracellular solution. Thus, during activity, changes in [Ca2+] may occur within the t-tubule lumen, which would, in turn, alter trans-sarcolemmal Ca2+ flux. To test this hypothesis, we used a computer model of rat ventricular myocyte including a t-tubular system. The action potentials in the two membranes were not significantly different, reflecting the electrical coupling of the two compartments. However, [Ca2+] within the t-tubule lumen decreased on each stimulus, and decreased cumulatively, until reaching a new dynamic steady state, with increasing stimulation rate. These data suggest that activity-dependent depletion of Ca2+ within the t-tubule lumen, adjacent to the trans-sarcolemmal Ca2+ flux pathways, decreases the Ca load, and hence lowers the inotropic
  • The majority of trans-sarcolemmal Ca2+ flux occurs across the t-tubule membrane, which therefore plays a key role in cardiac excitation-contraction coupling; however Ca2+ within the t-tubules does not equilibrate instantaneously with the bulk extracellular solution. Thus, during activity, changes in [Ca2+] may occur within the t-tubule lumen, which would, in turn, alter trans-sarcolemmal Ca2+ flux. To test this hypothesis, we used a computer model of rat ventricular myocyte including a t-tubular system. The action potentials in the two membranes were not significantly different, reflecting the electrical coupling of the two compartments. However, [Ca2+] within the t-tubule lumen decreased on each stimulus, and decreased cumulatively, until reaching a new dynamic steady state, with increasing stimulation rate. These data suggest that activity-dependent depletion of Ca2+ within the t-tubule lumen, adjacent to the trans-sarcolemmal Ca2+ flux pathways, decreases the Ca load, and hence lowers the inotropic (en)
  • Práce prezentuje výsledky simulací na modelu srdeční komorové buňky potkana ukazující vliv koncentračních změn tubulárních iontů Ca2+ (během buněčné aktivity) na intracelulární vápníkovou rovnováhu a inotropní stav komorových buněk. (cs)
Title
  • Změny [Ca2+] uvnitř t-tubulů mohou měnit inotropní stav srdečních ventrikulárních buněk potkana (cs)
  • Changes of [Ca2+] in the t-tubule lumen during activity may modulate the inotropic state of rat cardiac ventricular myocytes
  • Changes of [Ca2+] in the t-tubule lumen during activity may modulate the inotropic state of rat cardiac ventricular myocytes (en)
skos:prefLabel
  • Změny [Ca2+] uvnitř t-tubulů mohou měnit inotropní stav srdečních ventrikulárních buněk potkana (cs)
  • Changes of [Ca2+] in the t-tubule lumen during activity may modulate the inotropic state of rat cardiac ventricular myocytes
  • Changes of [Ca2+] in the t-tubule lumen during activity may modulate the inotropic state of rat cardiac ventricular myocytes (en)
skos:notation
  • RIV/00216224:14110/04:00011947!RIV09-GA0-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GP204/02/D129), Z(AV0Z2076919)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 557331
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/04:00011947
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • cardiac cell inotropy; tubular system; quantitative modelling (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [7EDC010B18FD]
http://linked.open...v/mistoKonaniAkce
  • Oxford
http://linked.open...i/riv/mistoVydani
  • Oxford
http://linked.open...i/riv/nazevZdroje
  • Proceedings of The Physiological Society
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Orchard, Clive
  • Pásek, Michal
  • Šimurda, Jiří
  • Christé, Georges
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • University of Oxford
http://localhost/t...ganizacniJednotka
  • 14110
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