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rdf:type
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Description
| - The majority of trans-sarcolemmal Ca2+ flux occurs across the t-tubule membrane, which therefore plays a key role in cardiac excitation-contraction coupling; however Ca2+ within the t-tubules does not equilibrate instantaneously with the bulk extracellular solution. Thus, during activity, changes in [Ca2+] may occur within the t-tubule lumen, which would, in turn, alter trans-sarcolemmal Ca2+ flux. To test this hypothesis, we used a computer model of rat ventricular myocyte including a t-tubular system. The action potentials in the two membranes were not significantly different, reflecting the electrical coupling of the two compartments. However, [Ca2+] within the t-tubule lumen decreased on each stimulus, and decreased cumulatively, until reaching a new dynamic steady state, with increasing stimulation rate. These data suggest that activity-dependent depletion of Ca2+ within the t-tubule lumen, adjacent to the trans-sarcolemmal Ca2+ flux pathways, decreases the Ca load, and hence lowers the inotropi
- The majority of trans-sarcolemmal Ca2+ flux occurs across the t-tubule membrane, which therefore plays a key role in cardiac excitation-contraction coupling; however Ca2+ within the t-tubules does not equilibrate instantaneously with the bulk extracellular solution. Thus, during activity, changes in [Ca2+] may occur within the t-tubule lumen, which would, in turn, alter trans-sarcolemmal Ca2+ flux. To test this hypothesis, we used a computer model of rat ventricular myocyte including a t-tubular system. The action potentials in the two membranes were not significantly different, reflecting the electrical coupling of the two compartments. However, [Ca2+] within the t-tubule lumen decreased on each stimulus, and decreased cumulatively, until reaching a new dynamic steady state, with increasing stimulation rate. These data suggest that activity-dependent depletion of Ca2+ within the t-tubule lumen, adjacent to the trans-sarcolemmal Ca2+ flux pathways, decreases the Ca load, and hence lowers the inotropi (en)
- Práce prezentuje výsledky simulací na modelu srdeční komorové buňky potkana ukazující vliv koncentračních změn tubulárních iontů Ca2+ (během buněčné aktivity) na intracelulární vápníkovou rovnováhu a inotropní stav komorových buněk. (cs)
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Title
| - Změny [Ca2+] uvnitř t-tubulů mohou měnit inotropní stav srdečních ventrikulárních buněk potkana (cs)
- Changes of [Ca2+] in the t-tubule lumen during activity may modulate the inotropic state of rat cardiac ventricular myocytes
- Changes of [Ca2+] in the t-tubule lumen during activity may modulate the inotropic state of rat cardiac ventricular myocytes (en)
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skos:prefLabel
| - Změny [Ca2+] uvnitř t-tubulů mohou měnit inotropní stav srdečních ventrikulárních buněk potkana (cs)
- Changes of [Ca2+] in the t-tubule lumen during activity may modulate the inotropic state of rat cardiac ventricular myocytes
- Changes of [Ca2+] in the t-tubule lumen during activity may modulate the inotropic state of rat cardiac ventricular myocytes (en)
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skos:notation
| - RIV/00216224:14110/04:00011947!RIV/2005/GA0/141105/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/04:00011947
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - cardiac cell inotropy, tubular system, quantitative modelling (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...v/mistoKonaniAkce
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http://linked.open...i/riv/mistoVydani
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http://linked.open...i/riv/nazevZdroje
| - Abstract Book of the Meeting of the Physiological Society
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Orchard, Clive
- Pásek, Michal
- Šimurda, Jiří
- Christé, Georges
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http://linked.open...vavai/riv/typAkce
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http://linked.open.../riv/zahajeniAkce
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number of pages
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http://purl.org/ne...btex#hasPublisher
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http://localhost/t...ganizacniJednotka
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