About: Ion concentration changes in transverse-axial tubular system of rat and guinea pig ventricular cardiomyocytes: a simulation study     Goto   Sponge   NotDistinct   Permalink

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Description
  • Práce prezentuje výsledky vyšetření velikosti iontově-koncentračních změn v transverzálně-axiálním tubulárním systému srdečních buněk laboratorního potkana a morčete provedené na matematických modelech. (cs)
  • We explored the extent of ion concentration changes in the transverse-axial tubular system (TATS) of rat and guinea pig ventricular cardiomyocytes by means of mathematical models. The simulations revealed significant changes of tubular calcium and potassium concentrations at different stimulation rates. In the rat model, the transient depletion of tubular Ca2+ increased from 7.3 % to 14 % (related to external level) and the transient accumulation of tubular K+ decreased from 4.3 % to 3 % with increase of stimulation rate from 1 Hz to 5 Hz. The guinea pig model, on the contrary, exhibited decrease of tubular Ca2+ depletion from 15.6 % to 7.1 % and increase of tubular K+ accumulation from 2.5 % to 3.4 % in the same frequency-range.
  • We explored the extent of ion concentration changes in the transverse-axial tubular system (TATS) of rat and guinea pig ventricular cardiomyocytes by means of mathematical models. The simulations revealed significant changes of tubular calcium and potassium concentrations at different stimulation rates. In the rat model, the transient depletion of tubular Ca2+ increased from 7.3 % to 14 % (related to external level) and the transient accumulation of tubular K+ decreased from 4.3 % to 3 % with increase of stimulation rate from 1 Hz to 5 Hz. The guinea pig model, on the contrary, exhibited decrease of tubular Ca2+ depletion from 15.6 % to 7.1 % and increase of tubular K+ accumulation from 2.5 % to 3.4 % in the same frequency-range. (en)
Title
  • Iontově-koncentrační změny v tubulárním systému srdečních buněk morčete a potkana: simulační studie (cs)
  • Ion concentration changes in transverse-axial tubular system of rat and guinea pig ventricular cardiomyocytes: a simulation study
  • Ion concentration changes in transverse-axial tubular system of rat and guinea pig ventricular cardiomyocytes: a simulation study (en)
skos:prefLabel
  • Iontově-koncentrační změny v tubulárním systému srdečních buněk morčete a potkana: simulační studie (cs)
  • Ion concentration changes in transverse-axial tubular system of rat and guinea pig ventricular cardiomyocytes: a simulation study
  • Ion concentration changes in transverse-axial tubular system of rat and guinea pig ventricular cardiomyocytes: a simulation study (en)
skos:notation
  • RIV/00216224:14110/04:00011945!RIV08-GA0-14110___
http://linked.open.../vavai/riv/strany
  • 56
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GP204/02/D129)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...dnocenehoVysledku
  • 568967
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/04:00011945
http://linked.open...riv/jazykVysledku
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  • cardiac cell; tubular system; quantitative modelling (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [46CAE722AE2E]
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  • Smolenice
http://linked.open...i/riv/mistoVydani
  • Smolenice
http://linked.open...i/riv/nazevZdroje
  • Abstract Book of the 4th International Symposium on Membrane Channels, Transporters and Receptors
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Pásek, Michal
  • Šimurda, Jiří
  • Christé, Georges
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
number of pages
http://purl.org/ne...btex#hasPublisher
  • Ústav molekulárnej fyziológie a genetiky SAV
http://localhost/t...ganizacniJednotka
  • 14110
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