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Description
  • We present a design of a model of rat ventricular cardiomyocyte with transverse-axial tubular system and the results of the first simulations of tubular ionic concentration changes at different stimulation rates. The morphology of tubular system and the distribution of ionic channels in tubular membrane were described to meet the recent data of Soeller and Cannell (1999) and of Orchard's group in Leeds. Exploration of activity-dependent changes in tubular ionic concentrations revealed an increase in relative Ca2+ depletion from 7.3 % to 14 % when increasing the stimulation frequency from 1 Hz to 5 Hz. Meanwhile, relative K+ accumulation decreased from 4.3 % to 3 %. These effects led to a limitation of intracellular Ca2+ overload.
  • We present a design of a model of rat ventricular cardiomyocyte with transverse-axial tubular system and the results of the first simulations of tubular ionic concentration changes at different stimulation rates. The morphology of tubular system and the distribution of ionic channels in tubular membrane were described to meet the recent data of Soeller and Cannell (1999) and of Orchard's group in Leeds. Exploration of activity-dependent changes in tubular ionic concentrations revealed an increase in relative Ca2+ depletion from 7.3 % to 14 % when increasing the stimulation frequency from 1 Hz to 5 Hz. Meanwhile, relative K+ accumulation decreased from 4.3 % to 3 %. These effects led to a limitation of intracellular Ca2+ overload. (en)
  • Práce prezentuje sestavení matematického modelu komorové buňky laboratorního potkana se zahrnutým popisem funkce transverzálně - axiálního tubulárního systému a představuje výsledky simulací odhalující velikost iontově-koncentračních změn uvnitř tubulárního systému potkana. (cs)
Title
  • Ionic concentration changes in the tubular system of rat ventricular cardiac cell model
  • Ionic concentration changes in the tubular system of rat ventricular cardiac cell model (en)
  • Iontově-koncetrační změny v tubulárním systému modelu komorové buňky potkana (cs)
skos:prefLabel
  • Ionic concentration changes in the tubular system of rat ventricular cardiac cell model
  • Ionic concentration changes in the tubular system of rat ventricular cardiac cell model (en)
  • Iontově-koncetrační změny v tubulárním systému modelu komorové buňky potkana (cs)
skos:notation
  • RIV/00216224:14110/04:00010869!RIV08-AV0-14110___
http://linked.open.../vavai/riv/strany
  • 1-9
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GP204/02/D129), Z(AV0Z2076919), Z(MSM 141100004)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 568976
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/04:00010869
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • cardiac cell; tubular system; quantitative modelling (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [51235FBDD776]
http://linked.open...v/mistoKonaniAkce
  • Svratka
http://linked.open...i/riv/mistoVydani
  • Svratka
http://linked.open...i/riv/nazevZdroje
  • Engineering Mechanics 2004
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Pásek, Michal
  • Šimurda, Jiří
  • Christé, Georges
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • Ústav termomechaniky AV ČR
https://schema.org/isbn
  • 80-85918-88-9
http://localhost/t...ganizacniJednotka
  • 14110
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