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  • A mathematical model of the interaction of propafenone with cardiac sodium channels is based on experimental data that demonstrate use-dependent effect of the drug. The model of CLANCY and RUDY (Circulation, 2002; 105: 1208-1213) is applied to describe Na-channel in absence of the drug. The values of rate constants of the drug-receptor reaction are fitted to experimental data by iterative computer simulations using a genetic algorithm. The model suggests that drug molecules have an access to the binding sites predominantly in the inactivated states and that accumulation of blocked channels in the slow inactivated state is responsible for the observed use- dependent effects. The results of quantitative modelling predict that propafenone (0.2 mmol/l) effectively suppresses premature excitations leaving the regular action potentials nearly unaffected.
  • A mathematical model of the interaction of propafenone with cardiac sodium channels is based on experimental data that demonstrate use-dependent effect of the drug. The model of CLANCY and RUDY (Circulation, 2002; 105: 1208-1213) is applied to describe Na-channel in absence of the drug. The values of rate constants of the drug-receptor reaction are fitted to experimental data by iterative computer simulations using a genetic algorithm. The model suggests that drug molecules have an access to the binding sites predominantly in the inactivated states and that accumulation of blocked channels in the slow inactivated state is responsible for the observed use- dependent effects. The results of quantitative modelling predict that propafenone (0.2 mmol/l) effectively suppresses premature excitations leaving the regular action potentials nearly unaffected. (en)
  • Práce popisuje sestavení matematického modelu interakce propafenonu se sodíkovými kanály srdečních buněk. Výsledky výpočtového modelování vlivu propafenonu na elektrickou aktivitu buněk ukázaly, že propafenon (0.2 mmol/l) účinně potlačuje předčasné excitace přičemž pravidelné excitace ponechává téměř neovlivněny. (cs)
Title
  • Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells
  • Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells (en)
  • Výpočtové modelování interakce propafenonu se sodíkovými kanály srdečních buněk (cs)
skos:prefLabel
  • Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells
  • Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells (en)
  • Výpočtové modelování interakce propafenonu se sodíkovými kanály srdečních buněk (cs)
skos:notation
  • RIV/00216224:14110/04:00010864!RIV09-GA0-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GP204/02/D129), Z(AV0Z2076919), Z(MSM 141100004)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 583350
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/04:00010864
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • cardiac cell; sodium current block; propafenone; quantitative modelling (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [C6981036961C]
http://linked.open...i/riv/nazevZdroje
  • Medical & Biological Engineering & Computing
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 42
http://linked.open...iv/tvurceVysledku
  • Pásek, Michal
  • Šimurda, Jiří
http://linked.open...ain/vavai/riv/wos
  • 000221059200003
http://linked.open...n/vavai/riv/zamer
issn
  • 0140-0118
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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