About: Vliv standardizovaného extraktu LI 160 (Hypericum perforatum) na metabolickou aktivitu cytochromu P-450 CYP1A2, CYP2C6, CYP2D2 a CYP3A1/2 v preklinickém experimentu.

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About: Vliv standardizovaného extraktu LI 160 (Hypericum perforatum) na metabolickou aktivitu cytochromu P-450 CYP1A2, CYP2C6, CYP2D2 a CYP3A1/2 v preklinickém experimentu. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Cílem experimentu bylo popsat vliv standardizovaného extraktu LI 160 na metabolickou aktivitu CYP2D1/2 na modelu izolovaných perfundovaných jater. Cílem experimentu bylo popsat vliv standardizovaného extraktu LI 160 na metabolickou aktivitu CYP2D1/2 na modelu izolovaných perfundovaných jater. (cs) St. Johns wort (Hypericum perforatum) is a popular over-the-counter dietary supplement and a herbal antidepressant that has been implicated in drug interactions with substrates of several cytochrome P450 (CYP) isozymes. The effects of the St. Johns wort extract (100 mg/kg, i.p., once daily for 10 days) on metabolic activity of CYP450 was assessed in the system of isolated perfused rat liver. The substrates used in this study were tolbutamide (CYP2C6), dextromethorphan (CYP2D2) and midazolam (CYP3A2). Validated HPLC method was used to quantify all compounds of interest. St. Johns wort administration affected CYP activity, caused a significant decline in AUC of dextromethorphan [F(4,31)=1511, p<0.001; PLSD, p<0.001] and AUC of midazolam [F(3,25)=221, p<0.001; PLSD, p=0.035] and a significant increase in AUC of tolbutamide [F(3,26)=200, p<0.001; PLSD, p<0.001]. St. Johns wort administration resulted in a significant induction of CYP2D2 and CYP3A2, and in a significant inhibition of CYP2C6 (en)
Title	Vliv standardizovaného extraktu LI 160 (Hypericum perforatum) na metabolickou aktivitu cytochromu P-450 CYP1A2, CYP2C6, CYP2D2 a CYP3A1/2 v preklinickém experimentu. Vliv standardizovaného extraktu LI 160 (Hypericum perforatum) na metabolickou aktivitu cytochromu P-450 CYP1A2, CYP2C6, CYP2D2 a CYP3A1/2 v preklinickém experimentu. (cs) Effect of standardized extract LI 160 (Hypericum perforatum) on metabolic activity of CYP-450 CYP1A2, CYP2C6, CYP2D2 and CYP3A1/2 in preclinical experiment. (en)
skos:prefLabel	Vliv standardizovaného extraktu LI 160 (Hypericum perforatum) na metabolickou aktivitu cytochromu P-450 CYP1A2, CYP2C6, CYP2D2 a CYP3A1/2 v preklinickém experimentu. Vliv standardizovaného extraktu LI 160 (Hypericum perforatum) na metabolickou aktivitu cytochromu P-450 CYP1A2, CYP2C6, CYP2D2 a CYP3A1/2 v preklinickém experimentu. (cs) Effect of standardized extract LI 160 (Hypericum perforatum) on metabolic activity of CYP-450 CYP1A2, CYP2C6, CYP2D2 and CYP3A1/2 in preclinical experiment. (en)
skos:notation	RIV/00216224:14110/04:00010731!RIV08-MSM-14110___
http://linked.open.../vavai/riv/strany	9-9
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 141100001)
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Pistovčáková, Jana Juřica, Jan Šulcová, Alexandra Tomandl, Josef McCaskey Hadašová, Eva Dostálek, Miroslav
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	592996
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/04:00010731
http://linked.open...riv/jazykVysledku	cze - čeština
http://linked.open.../riv/klicovaSlova	St Johns wort; CYP-450 (en)
http://linked.open.../riv/klicoveSlovo	CYP-450 St Johns wort
http://linked.open...ontrolniKodProRIV	[B005EDF8E514]
http://linked.open...v/mistoKonaniAkce	Brno
http://linked.open...i/riv/mistoVydani	Brno
http://linked.open...i/riv/nazevZdroje	In MediFórum.
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2004
http://linked.open...iv/tvurceVysledku	Dostálek, Miroslav Juřica, Jan Tomandl, Josef Šulcová, Alexandra Linhart, Igor Pistovčáková, Jana McCaskey Hadašová, Eva
http://linked.open...vavai/riv/typAkce	CST - Celostátní
http://linked.open.../riv/zahajeniAkce	2004-01-01 (xsd:date)
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20141100001
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Kongresové centrum Brno, a.s.,
https://schema.org/isbn	80-86607-13-5
http://localhost/t...ganizacniJednotka	14110

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