About: Heterozygote AG variant of -596 A/G IL-6 gene polymorphism is a marker for cutaneous T-cell lymphoma (CTCL)

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About: Heterozygote AG variant of -596 A/G IL-6 gene polymorphism is a marker for cutaneous T-cell lymphoma (CTCL) Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Prokázali jsme signifikantní rozdíl v distribuci genotypu -596 A/G IL-6 mezi pacienty s CTCL a kontrolami (P=0,002) s téměř trojnásobným odds ratio pro heterozygotní genotyp AG u pacientů s CTCL orpoti kontrolám (OR=2,64, P=0,002). (cs) The aim of the study was to investigate possible associations of IL-6 gene polymorphisms (596 A/G and 174 C/G) with cutaneous T-cell lymphoma (CTCL). In the case-control study, genotype distributions and allelic frequencies in two promoter IL-6 gene polymorphisms in the group of 63 Czech patients with CTCL were compared to those of 105 control non-CTCL subjects matched for aged and sex. The IL-6 gene polymorphisms were determined by PCR with following restriction analysis. A significant difference of 596 A/G IL-6 genotype distribution was found between the CTCL patients and the controls (P=0.002) with almost threefold odds ratio for the heterozygote (AG) genotype in CTCL patients (OR=2.64, P=0.002). No significant differences in genotype distribution and/or allelic frequency of functional -174C/G IL-6 gene polymorphism were observed. The double heterozygote AGCG of both IL-6 promoter polymorphisms was associated with CTCL (OR=2.24, 95% confidence interval 1.17-4.28, P=0.01). Thus, the heterozygote var The aim of the study was to investigate possible associations of IL-6 gene polymorphisms (596 A/G and 174 C/G) with cutaneous T-cell lymphoma (CTCL). In the case-control study, genotype distributions and allelic frequencies in two promoter IL-6 gene polymorphisms in the group of 63 Czech patients with CTCL were compared to those of 105 control non-CTCL subjects matched for aged and sex. The IL-6 gene polymorphisms were determined by PCR with following restriction analysis. A significant difference of 596 A/G IL-6 genotype distribution was found between the CTCL patients and the controls (P=0.002) with almost threefold odds ratio for the heterozygote (AG) genotype in CTCL patients (OR=2.64, P=0.002). No significant differences in genotype distribution and/or allelic frequency of functional -174C/G IL-6 gene polymorphism were observed. The double heterozygote AGCG of both IL-6 promoter polymorphisms was associated with CTCL (OR=2.24, 95% confidence interval 1.17-4.28, P=0.01). Thus, the heterozygote var (en)
Title	Heterozygote AG variant of -596 A/G IL-6 gene polymorphism is a marker for cutaneous T-cell lymphoma (CTCL) Heterozygote AG variant of -596 A/G IL-6 gene polymorphism is a marker for cutaneous T-cell lymphoma (CTCL) (en) Heterozygot AG polymorfismu -596 A/G v genu pro IL-6 je marker pro kožní T-lymfom (CTCL) (cs)
skos:prefLabel	Heterozygote AG variant of -596 A/G IL-6 gene polymorphism is a marker for cutaneous T-cell lymphoma (CTCL) Heterozygote AG variant of -596 A/G IL-6 gene polymorphism is a marker for cutaneous T-cell lymphoma (CTCL) (en) Heterozygot AG polymorfismu -596 A/G v genu pro IL-6 je marker pro kožní T-lymfom (CTCL) (cs)
skos:notation	RIV/00216224:14110/04:00010704!RIV09-MSM-14110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 141100002)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Vašků, Anna Bienertová-Vašků, Julie Vašků, Vladimír Pávková Goldbergová, Monika
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	566087
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/04:00010704
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CTCL; IL-6; Gene polymorphism; Marker (en)
http://linked.open.../riv/klicoveSlovo	IL-6 Gene polymorphism Marker CTCL
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[4994268A0AEB]
http://linked.open...i/riv/nazevZdroje	Clinical Immunology
http://linked.open...in/vavai/riv/obor	FO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	113
http://linked.open...iv/tvurceVysledku	Bienertová Vašků, Julie Vašků, Anna Vašků, Vladimír Pávková Goldbergová, Monika
http://linked.open...ain/vavai/riv/wos	000224975700007
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20141100002
issn	1521-6616
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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