| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - Vascular lesion development is associated with an accumulation of extracellular matrix proteins within the vessel wall. The proteins are degraded by matrix metalloproteinases. There is also evidence indicating a participation of the MMPs in the weakening of atherosclerotic plaque that predisposes to lesion disruption. The aim of the study was to test an association among haplotypes of four single nucleotide MMP-2 promoter polymorphisms and the angiographically confirmed coronary triplevessel disease. Incidence of haplotypes of four MMP-2 promoter polymorphisms (-1575 G/A, -1306C/T, -790T/G and -735C/T) determined by PCR reactions with restriction analyses in 187 patients with coronary triple-vessel disease (153 men, 34 women, age median 65 years) was compared to 196 control subjects without clinical signs of CHD (131 men and 65 women, age median 60 years).The incidence of two similar haplotypes was found to be different between patients and healthy subjects. The haplotype GCTC was more frequent in the
- Vascular lesion development is associated with an accumulation of extracellular matrix proteins within the vessel wall. The proteins are degraded by matrix metalloproteinases. There is also evidence indicating a participation of the MMPs in the weakening of atherosclerotic plaque that predisposes to lesion disruption. The aim of the study was to test an association among haplotypes of four single nucleotide MMP-2 promoter polymorphisms and the angiographically confirmed coronary triplevessel disease. Incidence of haplotypes of four MMP-2 promoter polymorphisms (-1575 G/A, -1306C/T, -790T/G and -735C/T) determined by PCR reactions with restriction analyses in 187 patients with coronary triple-vessel disease (153 men, 34 women, age median 65 years) was compared to 196 control subjects without clinical signs of CHD (131 men and 65 women, age median 60 years).The incidence of two similar haplotypes was found to be different between patients and healthy subjects. The haplotype GCTC was more frequent in the (en)
- Rozvoj poškození cévní stěny je asociován s akumulací proteinů extracelulární matrix. Tyto proteiny jsou degradovány matrix metaloproteinázami. Cílem studie bylo proto testovat asociaci mezi haplotypy čtyř promotorových polymorfismů a nemocí tří koronárních tepen, potvrzenou angiograficky. Frekvence haplotypů byly srovnány se skupinou 196 kontrolních osob bez klinických příznaků koronární nemoci. Prokázali jsme, že haplotyp GCTC byl častěji přítomen u pacientů (P=0,01), kdežto haplotyp GCGC byl pozorován jen u zdravých osob(P=0,001). (cs)
|
| Title
| - Haplotyp čtyř polymorfismů v promotoru genu pro MMP-2 (-1575G/A, -1306C/T, -790T/G a -735C/T) je asociován s nemocí tří koronárních tepen (cs)
- A haplotype constituted of four MMP-2 promoter polymorphisms (-1575G/A, -1306C/T, -790T/G and -735C/T) is associated with coronary triple- vessel disease
- A haplotype constituted of four MMP-2 promoter polymorphisms (-1575G/A, -1306C/T, -790T/G and -735C/T) is associated with coronary triple- vessel disease (en)
|
| skos:prefLabel
| - Haplotyp čtyř polymorfismů v promotoru genu pro MMP-2 (-1575G/A, -1306C/T, -790T/G a -735C/T) je asociován s nemocí tří koronárních tepen (cs)
- A haplotype constituted of four MMP-2 promoter polymorphisms (-1575G/A, -1306C/T, -790T/G and -735C/T) is associated with coronary triple- vessel disease
- A haplotype constituted of four MMP-2 promoter polymorphisms (-1575G/A, -1306C/T, -790T/G and -735C/T) is associated with coronary triple- vessel disease (en)
|
| skos:notation
| - RIV/00216224:14110/04:00010702!RIV09-MSM-14110___
|
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| |
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/04:00010702
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - Triple-vessel disease; Matrix metalloproteinases; Atherosclerotic plaque (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Groch, Ladislav
- Izakovičová-Hollá, Lydie
- Vašků, Anna
- Pávková Goldbergová, Monika
- Šišková, Lenka
- Beránek, Michal
- Tschöplová, Svatava
- Znojil, Vladimír
- Vácha, Jiří
|
| http://linked.open...ain/vavai/riv/wos
| |
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
| http://localhost/t...ganizacniJednotka
| |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)