About: Involvement of 5-HT1 and 5-HT2 receptor activity in methamphetamine i.v. self-administration in rats depressed by olfactory bulbectomy     Goto   Sponge   NotDistinct   Permalink

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Description
  • The influence of 5-HT1 and 5-HT2 receptor antagonists on methamphetamine intake was analysed in both, naive rats and those depressed by olfactory bulbectomy. Our results indicate that the involvement of 5-HT2 rather than 5-HT1 receptor is important for methamphetamine reward properties what corresponds with the outcomes of methamphetamine discriminative studies. Thus, 5-HT2 receptor antagonists referred to attenuate the withdrawal signs of drugs of abuse could be of benefit also in treatment of methamphetamine dependence, mainly in addicts with depressive disorders.
  • The influence of 5-HT1 and 5-HT2 receptor antagonists on methamphetamine intake was analysed in both, naive rats and those depressed by olfactory bulbectomy. Our results indicate that the involvement of 5-HT2 rather than 5-HT1 receptor is important for methamphetamine reward properties what corresponds with the outcomes of methamphetamine discriminative studies. Thus, 5-HT2 receptor antagonists referred to attenuate the withdrawal signs of drugs of abuse could be of benefit also in treatment of methamphetamine dependence, mainly in addicts with depressive disorders. (en)
  • Výsledky ukazují na významný podíl aktivity 5-HT2 receptorového systémů v procesech odměny u potaknů v modelu deprese. (cs)
Title
  • Vliv 5-HT1 a 5-HT2 receptorů na aktivitu v i.v. self-administraci metamfetaminu u potkanů v modelu deprese vyvolané olfaktorickou bulbektomií (cs)
  • Involvement of 5-HT1 and 5-HT2 receptor activity in methamphetamine i.v. self-administration in rats depressed by olfactory bulbectomy
  • Involvement of 5-HT1 and 5-HT2 receptor activity in methamphetamine i.v. self-administration in rats depressed by olfactory bulbectomy (en)
skos:prefLabel
  • Vliv 5-HT1 a 5-HT2 receptorů na aktivitu v i.v. self-administraci metamfetaminu u potkanů v modelu deprese vyvolané olfaktorickou bulbektomií (cs)
  • Involvement of 5-HT1 and 5-HT2 receptor activity in methamphetamine i.v. self-administration in rats depressed by olfactory bulbectomy
  • Involvement of 5-HT1 and 5-HT2 receptor activity in methamphetamine i.v. self-administration in rats depressed by olfactory bulbectomy (en)
skos:notation
  • RIV/00216224:14110/04:00010699!RIV08-MSM-14110___
http://linked.open.../vavai/riv/strany
  • 45-45
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 141100001)
http://linked.open...iv/cisloPeriodika
  • Suppl. 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 568954
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/04:00010699
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • rats; 5-HT1 and 5-HT2 receptor ligands; methamphetamine; dependence; depression (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [3D39ACA96DB5]
http://linked.open...i/riv/nazevZdroje
  • Fundamental & Clinical Pharmacology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 18
http://linked.open...iv/tvurceVysledku
  • Nováková, Jana
  • Šulcová, Alexandra
  • Pistovčáková, Jana
  • Vinklerová, Jana
http://linked.open...n/vavai/riv/zamer
issn
  • 1744-3377
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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