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  • Numerous studies refer to the important involvement of N-methyl-D-aspartate (NMDA) receptors in the development and expression of behavioural sensitization. Activating antiepileptic drugs of the 3rd generation, such as felbamate (FEL) also invoke psychotropic effects. They may possess attention-enhancing and antidepressant efficacy, cause anxiety, insomnia, and agitation. All pharmacological mechanisms of felbamate are not fully elucidated yet, but many of clinical effects may be related to the inhibition of NMDA currents. The present study focuses on investigation of felbamate influence on sensitization to methamphetamine effects on mouse locomotor/exploratory behaviour in the open field.
  • Numerous studies refer to the important involvement of N-methyl-D-aspartate (NMDA) receptors in the development and expression of behavioural sensitization. Activating antiepileptic drugs of the 3rd generation, such as felbamate (FEL) also invoke psychotropic effects. They may possess attention-enhancing and antidepressant efficacy, cause anxiety, insomnia, and agitation. All pharmacological mechanisms of felbamate are not fully elucidated yet, but many of clinical effects may be related to the inhibition of NMDA currents. The present study focuses on investigation of felbamate influence on sensitization to methamphetamine effects on mouse locomotor/exploratory behaviour in the open field. (en)
  • Výsledky potvrdily preventivní efekt felbamátu k expresi sensitizace k behaviorálním účinkům dávky metafetaminu po dané po vysazení opakového podávání této drogy. (cs)
Title
  • The influence of felbamate on sensitization to methamphetamine behavioural effects in mice.
  • The influence of felbamate on sensitization to methamphetamine behavioural effects in mice. (en)
  • Vliv felbamátu na rozvoj sensitizace k behaviorálním účinkům metamfetqaminu u myší (cs)
skos:prefLabel
  • The influence of felbamate on sensitization to methamphetamine behavioural effects in mice.
  • The influence of felbamate on sensitization to methamphetamine behavioural effects in mice. (en)
  • Vliv felbamátu na rozvoj sensitizace k behaviorálním účinkům metamfetqaminu u myší (cs)
skos:notation
  • RIV/00216224:14110/04:00010402!RIV08-MSM-14110___
http://linked.open.../vavai/riv/strany
  • S346-S346
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 141100001)
http://linked.open...iv/cisloPeriodika
  • Suppl. 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 567868
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/04:00010402
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • behavioural sensitization; methamphetamine; felbamate; mice (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [EE40F95FC996]
http://linked.open...i/riv/nazevZdroje
  • European Neuropsychopharmacology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 14
http://linked.open...iv/tvurceVysledku
  • Landa, Leoš
  • Šulcová, Alexandra
  • Šlais, Karel
http://linked.open...n/vavai/riv/zamer
issn
  • 0924-977X
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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