| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - Třezalka tečkovaná (Hypericum perforatum) je součástí volně prodejných potravních doplňků a s úspěchem se používívá jako přírodní antidepresivum, byly u ní však referovány četné interakce se subtráty enzymatického systému cytochromu P-450. Interakce látek a třezalky tečkované jsou hojně diskutovaným problémem v odborné literatuře. Klinické studiu poukazují na skutečnost, že extrakt třezalky tečkované významně snižuje plazmatickou hladinu digoxinu. Studie provedené se zdravými dobrovolníky i pacienty s depresivní poruchou referují o snižování plazmatických hladin i dalších léčiv - jsou to indinavir, nevirapin, cyklosporin, teofylin, midazolam, simvastatin, ethinyestradiol, warfarin, amitriptylin a nortriptylin. Cílem předkládané studie bylo popsat vliv standardizovaného extraktu LI 160 - 100 mg/kg, i.p., jednou denně po dobu 10ti dnů - (obsahující v jedné dávce 280 g hypericinu, 300 g pseudohypericinu, 6.5 mg hyperforinu a 10 mg hyperosidu) na metabolickou aktivitu klinicky nejvýznamnějších izoenzymů c (cs)
- St. Johns wort (Hypericum perforatum) is a popular over-the-counter dietary supplement and a herbal antidepressant that has been implicated in drug interactions with substrates of several cytochrome P450 (CYP) isozymes. Drug interactions linked to the use of St. Johns wort are now surfacing in the scientific literature. A clinical trial showed that co-administration of St. Johns wort extracts with digoxin resulted in significantly decreased drug plasma levels. Studies in healthy individuals and patients found that St. Johns wort preparations reduced significantly plasma levels of indinavir, nevirapine, cyclosporine, theophylline, midazolam, simvastatin, ethinyestradiol, warfarin and phenprocoumon, amitriptyline and nortriptyline. The aim of our study was to ascertain the influence of standardized extract LI 160 - 100 mg/kg, i.p., once daily for 10 days - (containing 280 g of hypericin, 300 g of pseudohypericin, 6.5 mg of hyperforin and 10 mg of hyperosid in the single dose of 100 mg/kg) on metabolic a
- St. Johns wort (Hypericum perforatum) is a popular over-the-counter dietary supplement and a herbal antidepressant that has been implicated in drug interactions with substrates of several cytochrome P450 (CYP) isozymes. Drug interactions linked to the use of St. Johns wort are now surfacing in the scientific literature. A clinical trial showed that co-administration of St. Johns wort extracts with digoxin resulted in significantly decreased drug plasma levels. Studies in healthy individuals and patients found that St. Johns wort preparations reduced significantly plasma levels of indinavir, nevirapine, cyclosporine, theophylline, midazolam, simvastatin, ethinyestradiol, warfarin and phenprocoumon, amitriptyline and nortriptyline. The aim of our study was to ascertain the influence of standardized extract LI 160 - 100 mg/kg, i.p., once daily for 10 days - (containing 280 g of hypericin, 300 g of pseudohypericin, 6.5 mg of hyperforin and 10 mg of hyperosid in the single dose of 100 mg/kg) on metabolic a (en)
|
| Title
| - Effect of St Johns wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver
- Effect of St Johns wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver (en)
- Vliv standardizovaného extraktu LI 160 (Hypericum perforatum) na metabolickou aktivitu vybraných izoforem cytochromu P450 v preklinickém experimentu (cs)
|
| skos:prefLabel
| - Effect of St Johns wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver
- Effect of St Johns wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver (en)
- Vliv standardizovaného extraktu LI 160 (Hypericum perforatum) na metabolickou aktivitu vybraných izoforem cytochromu P450 v preklinickém experimentu (cs)
|
| skos:notation
| - RIV/00216224:14110/04:00010021!RIV08-MSM-14110___
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/04:00010021
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - izolated perfused liver; Hypericum perforatum; CYP450 (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...v/mistoKonaniAkce
| |
| http://linked.open...i/riv/mistoVydani
| |
| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...iv/tvurceVysledku
| - Dostálek, Miroslav
- Pistovčáková, Jana
|
| http://linked.open...vavai/riv/typAkce
| |
| http://linked.open.../riv/zahajeniAkce
| |
| http://linked.open...n/vavai/riv/zamer
| |
| number of pages
| |
| http://purl.org/ne...btex#hasPublisher
| - Masarykova univerzita v Brně. Lékařská fakulta
|
| http://localhost/t...ganizacniJednotka
| |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)