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| Description
| - Úvod: důležitou vlastností moderních antihypertenziv je jejich 24hodinová účinnost. pokud má lék trough/peak poměr nad 50%, může být podáván jedenkrát denně. Pulsový tlak (PT) se zvyšuje s věkem a lépe koreluje s kardiovaskulární nemocností a úmrtností hypertoniků než samotný systolický nebo diastolický tlak. zatím neznáme optimální hodnoty PT v různých věkových kategoriích a s přítomností dalších rizik a onemocnění. Metoda: měření tlaku (TK) pomocí 24hodinového monitorování (ABPM) (SPACELAB 90207) a užitím rtuťového sfygmomanometru (germed) dle kritérií WHO. Pro hodnotu peak jsme použili průměrný tlak ve 3-6 hodině po podání léku nebo placeba, pro hodnotu trough průměrnou hodnotu TK ve 22-24 hodině po podání léku, 30 minut po ranním vstávání s vyloučením vlivu nemocničního prostředí. Pro statistické zpracování jsme použily program Statistica for Windows 98, StatSoft, Tulsa. Vyšetřili jsme 50 pacientů průměrného věku 39 +- 10 roků, před a po 3 měsíční léčbě 20 mg betaxolol hydrochloridu, podávaného je (cs)
- Background: One of the important characteristic features of the new antihypertensives drugs is its 24-hour effectiveness. If the drug reaches the mean trough/peak over 50% it can be dosed once daily. The pulse pressure (PP) increases with the age and correlates better with the organs damage and with the cardio-vascular disease and mortality of hypertonic patients, than the systolic or diastolic pressure itself. The optimal values of PP have not been known yet in various age categories and patients with other associated risk factors and diseases. Methods: Blood pressure (BP) measurement using 24-hour ambulatory blood pressure monitoring (ABPM) (SPACELAB 90207) and mercury sphygmomanometer (Germed ) according to the WHO criteria. For the peak value we used the mean BP from the 3rd - 6th hour after the using of betaxolol hydrochloride or placebo, for the trough value the mean BP from the 22nd - 24th hour of the measurement was used, 30 minutes after getting up in the morning and excluding the influenc
- Background: One of the important characteristic features of the new antihypertensives drugs is its 24-hour effectiveness. If the drug reaches the mean trough/peak over 50% it can be dosed once daily. The pulse pressure (PP) increases with the age and correlates better with the organs damage and with the cardio-vascular disease and mortality of hypertonic patients, than the systolic or diastolic pressure itself. The optimal values of PP have not been known yet in various age categories and patients with other associated risk factors and diseases. Methods: Blood pressure (BP) measurement using 24-hour ambulatory blood pressure monitoring (ABPM) (SPACELAB 90207) and mercury sphygmomanometer (Germed ) according to the WHO criteria. For the peak value we used the mean BP from the 3rd - 6th hour after the using of betaxolol hydrochloride or placebo, for the trough value the mean BP from the 22nd - 24th hour of the measurement was used, 30 minutes after getting up in the morning and excluding the influenc (en)
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| Title
| - Poměr trough/peak betaxolol hydrochloridu a jeho vliv na pulsní tlak u pacientů s čerstvě zjištěnou hypertenzí. (cs)
- Trough/peak ratio and effect on pulse pressure of betaxolol hydrochloride in patients with newly diagnosed hypertension.
- Trough/peak ratio and effect on pulse pressure of betaxolol hydrochloride in patients with newly diagnosed hypertension. (en)
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| skos:prefLabel
| - Poměr trough/peak betaxolol hydrochloridu a jeho vliv na pulsní tlak u pacientů s čerstvě zjištěnou hypertenzí. (cs)
- Trough/peak ratio and effect on pulse pressure of betaxolol hydrochloride in patients with newly diagnosed hypertension.
- Trough/peak ratio and effect on pulse pressure of betaxolol hydrochloride in patients with newly diagnosed hypertension. (en)
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| skos:notation
| - RIV/00216224:14110/04:00009968!RIV/2005/MSM/141105/N
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/04:00009968
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Trough/peak ratio, ambulatory blodd pressure monitoring, betablockers (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...v/mistoKonaniAkce
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| http://linked.open...i/riv/mistoVydani
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...iv/tvurceVysledku
| - Souček, Miroslav
- Kára, Tomáš
- Orban, Marek
- Fráňa, Petr
- Řiháček, Ivan
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| http://linked.open...vavai/riv/typAkce
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| http://linked.open.../riv/zahajeniAkce
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://purl.org/ne...btex#hasPublisher
| - London : Lippincott Williams and Wilkins.
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| http://localhost/t...ganizacniJednotka
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