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| Description
| - Background: Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional endocytic receptor with an important role in regulating the activity of proteinases in extracellular matrix. Several studies have also described its role in intracellular signaling. Previous studies showed that the expression of LRP1 is related to invasiveness of cancer cells. However, recent data on LRP1 suggest that this receptor can also be involved in tumor establishment and progression. Methods: We investigated an association between the C766T polymorphism of the third exon of the LRP1 gene and breast cancer in a sample of women of Caucasian origin. Allele and genotype frequencies of this polymorphism were assessed in 164 women with breast cancer and in 183 age-compatible women without a history of any cancer disease. Results: An increase in LRP1 T allele frequency in subjects with breast cancer was observed compared with controls (0.21 versus 0.15, P=0.01963). A significant excess of genotypes with the T a
- Background: Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional endocytic receptor with an important role in regulating the activity of proteinases in extracellular matrix. Several studies have also described its role in intracellular signaling. Previous studies showed that the expression of LRP1 is related to invasiveness of cancer cells. However, recent data on LRP1 suggest that this receptor can also be involved in tumor establishment and progression. Methods: We investigated an association between the C766T polymorphism of the third exon of the LRP1 gene and breast cancer in a sample of women of Caucasian origin. Allele and genotype frequencies of this polymorphism were assessed in 164 women with breast cancer and in 183 age-compatible women without a history of any cancer disease. Results: An increase in LRP1 T allele frequency in subjects with breast cancer was observed compared with controls (0.21 versus 0.15, P=0.01963). A significant excess of genotypes with the T a (en)
- %22Low-density lipoprotein receptor-related protein 1%22 (LRP1) je multifunkční endocytický receptor s důležitou rolí při regulaci aktivity proteáz v extracelulární matrix. Několik studií popsalo také jeho roli ve vnitrobuněčné signalizaci. Bylo prokázáno, že exprese LRP1 má vztah k invazivitě nádorových buněk. Podle nedávných zjištění se však LRP1 může podílet také na nádorové transformaci buněk. V naší práci jsme studovali asociaci mezi genovým polymorfizmem C766T ve třetím exonu genu pro LRP1 a karcinomem prsu na vzorku žen indoevropské rasy. Alelické a genotypové frekvence sledovaného polymorfizmu byly určeny u 164 žen s karcinomem prsu a u 183 věkově odpovídajících kontrol. Mezi ženami s karcinomem prsu byla pozorována větší četnost alely T sledovaného polymorfizmu v porovnání s kontrolní populací (0.21 versus 0.15, P=0.01963). Bylo pozorováno také signifikantně větší zastoupení nositelek alespoň jedné T alely (homozygotů a heterozygotů) mezi pacientkami s karcinomem prsu (poměr šancí 1.743, 95% inte (cs)
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| Title
| - Genový polymorfismus C766T v genu pro low-density lipoprotein receptor-related protein 1 ( LRP1) a náchylnost ke karcinomu prsu (cs)
- C766T low-density lipoprotein receptor-related protein 1 ( LRP1) gene polymorphism and susceptibility to breast cancer
- C766T low-density lipoprotein receptor-related protein 1 ( LRP1) gene polymorphism and susceptibility to breast cancer (en)
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| skos:prefLabel
| - Genový polymorfismus C766T v genu pro low-density lipoprotein receptor-related protein 1 ( LRP1) a náchylnost ke karcinomu prsu (cs)
- C766T low-density lipoprotein receptor-related protein 1 ( LRP1) gene polymorphism and susceptibility to breast cancer
- C766T low-density lipoprotein receptor-related protein 1 ( LRP1) gene polymorphism and susceptibility to breast cancer (en)
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| skos:notation
| - RIV/00216224:14110/03:00009856!RIV09-MSM-14110___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/03:00009856
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - breast cancer; case-control study; genetic polymorphism; low-density lipoprotein receptor-related protein 1 (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Beneš, Petr
- Izakovičová-Hollá, Lydie
- Jurajda, Michal
- Žaloudík, Jan
- Vácha, Jiří
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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