| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - The antiepileptics of the 3rd generation are currently reported from clinics to show antidepressant effects. Therefore the study investigated one of them, felbamate for its potential anti-depressant activity in an animal model based on agonistic interactions of non-aggressive group-housed male mice with aggressive isolates. After the repeated agonistic interactions the group-housed mice exhibit depressed locomotor/exploratory behaviour in a novel open field arena, which can be disinhibited by clinically used antidepressants (Steinberg H, 1990). In our experiment the group-housed mice responded to felbamate at the doses 60 and 240 mg/kg orally by a significant (p < 0.05) disinhibiton of their suppresed locomotor/exploratory behaviour, thus felbamate produced an antidepresive-like effect, which is in correspondence with clinical reports on a potential antidepressant action of felbamate.
- The antiepileptics of the 3rd generation are currently reported from clinics to show antidepressant effects. Therefore the study investigated one of them, felbamate for its potential anti-depressant activity in an animal model based on agonistic interactions of non-aggressive group-housed male mice with aggressive isolates. After the repeated agonistic interactions the group-housed mice exhibit depressed locomotor/exploratory behaviour in a novel open field arena, which can be disinhibited by clinically used antidepressants (Steinberg H, 1990). In our experiment the group-housed mice responded to felbamate at the doses 60 and 240 mg/kg orally by a significant (p < 0.05) disinhibiton of their suppresed locomotor/exploratory behaviour, thus felbamate produced an antidepresive-like effect, which is in correspondence with clinical reports on a potential antidepressant action of felbamate. (en)
- Antiepileptiká 3. generace jsou v současnosti referovány pro jejich využití v léčbě deprese. Testovali jsme proto antiepileptikum felbamát ve zvířecím modelu agonistických interakcí skupinově-ustájených myší s agresivními myšími izolátmi. Po opakovaných sociálních interakcích vykazují skupinově-ustájené myši sníženou lokomoční aktivitu v testu otevřeného pole, která může být desinhibována působením klinicky uživaných antidepresiv (Steinberg H, 1990). V našem experimentu způsobil felbamát v dávkách 60 a 240 mg/kg p.o. (p < 0.05) desinhibici lokomočně-exploračního chování skupinově-ustájených myší v testu otevřeného pole, což v souladu s klinickými údaji o potenciálním antidepresivním účinku felbamátu svědčí pro možnost jeho využití v léčbě deprese. (cs)
|
| Title
| - Účinky felbamátu na explorační chování myší jsou podobné účinkům antidepresiv (cs)
- Antidepressive-like felbamate effects on exploratory behaviour in mice
- Antidepressive-like felbamate effects on exploratory behaviour in mice (en)
|
| skos:prefLabel
| - Účinky felbamátu na explorační chování myší jsou podobné účinkům antidepresiv (cs)
- Antidepressive-like felbamate effects on exploratory behaviour in mice
- Antidepressive-like felbamate effects on exploratory behaviour in mice (en)
|
| skos:notation
| - RIV/00216224:14110/03:00009515!RIV08-MSM-14110___
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| |
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/03:00009515
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - agonistic interactions; felbamate; antidepressant; animal model (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| |
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Šulcová, Alexandra
- Pistovčáková, Jana
|
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
| http://localhost/t...ganizacniJednotka
| |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)