About: Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin.

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About: Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Avuilse ventrálního kořene spinálního nervu způsobuje ztrátu motoneuronů (cs) The ventral root avulsion results in the loss of motoneurons in the corresponding spinal cord segment. In the present experiments we have tested a neuroprotective effect of Cerebrolysin and insulin-like growth factor-I (IGF-I) on survival of avulsed motoneurons after their chronic intrathecal administration in the adult rats. We have found that avulsion of the C5 ventral roots results in significant loss of motoneurons in the same spinal cord segment due mainly to apoptosis. In comparison to the untreated control rats, the amount of motoneuron survival in avulsed ventral horn was significantly higher after 4 weeks intrathecal administration of Cerebrolysin and IGF-I. No significant differences were observed between effects of Cerebrolysin and IGF-I in our experimental model. The results suggest neuroprotective effect of Cerebrolysin on survival of motoneurons following the ventral root avulsion. The ventral root avulsion results in the loss of motoneurons in the corresponding spinal cord segment. In the present experiments we have tested a neuroprotective effect of Cerebrolysin and insulin-like growth factor-I (IGF-I) on survival of avulsed motoneurons after their chronic intrathecal administration in the adult rats. We have found that avulsion of the C5 ventral roots results in significant loss of motoneurons in the same spinal cord segment due mainly to apoptosis. In comparison to the untreated control rats, the amount of motoneuron survival in avulsed ventral horn was significantly higher after 4 weeks intrathecal administration of Cerebrolysin and IGF-I. No significant differences were observed between effects of Cerebrolysin and IGF-I in our experimental model. The results suggest neuroprotective effect of Cerebrolysin on survival of motoneurons following the ventral root avulsion. (en)
Title	Záchrana spinálních motoneuronů před smrtí způsobenou avulzí spnálních kořenů (cs) Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin. Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin. (en)
skos:prefLabel	Záchrana spinálních motoneuronů před smrtí způsobenou avulzí spnálních kořenů (cs) Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin. Rescue of rat spinal motoneurons from avulsion-induced cell death by intrathecal administration of IGF-I and Cerebrolysin. (en)
skos:notation	RIV/00216224:14110/03:00009288!RIV09-MZ0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NF6658), Z(MSM 141100001)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Dubový, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	625330
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/03:00009288
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	motoneuron; promotion; neurotrophic (en)
http://linked.open.../riv/klicoveSlovo	promotion motoneuron neurotrophic
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[19D4D26CA55F]
http://linked.open...i/riv/nazevZdroje	Annals of Anatomy
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Alternative approaches in brachial plexus reconstruction and experimental evaluation of various neurotrophic factors action on direct and collateral reinnervation
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	185
http://linked.open...iv/tvurceVysledku	Dubový, Petr Haninec, Pavel Stejskal, Lubomír Houšťava, Ladislav
http://linked.open...ain/vavai/riv/wos	000183351200007
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20141100001
issn	0940-9602
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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