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  • Byly analyzovány komponenty celkového iontového proudu zodpovědné za frekvenčně-závislé změny akčního napětí metodou vnuceného akčního napětí u izolovaných komorových srdečních buněk potkana. (cs)
  • Components of the total ionic current responsible for rate-dependent changes of action potential (AP) configuration were analyzed by the AP clamp method in isolated rat ventricular myocytes. The results demonstrate that besides Ca2+-mediated currents, cumulative inactivation of the transient outward current Ito significantly participates on the rate-dependent variability of AP configuration. Under the effect of antiarrhythmic drug ajmaline (30mikromol/l), the fast sodium current INa causes marked changes in the repolarization phase of AP, very likely as a consequence of its use-dependent block.
  • Components of the total ionic current responsible for rate-dependent changes of action potential (AP) configuration were analyzed by the AP clamp method in isolated rat ventricular myocytes. The results demonstrate that besides Ca2+-mediated currents, cumulative inactivation of the transient outward current Ito significantly participates on the rate-dependent variability of AP configuration. Under the effect of antiarrhythmic drug ajmaline (30mikromol/l), the fast sodium current INa causes marked changes in the repolarization phase of AP, very likely as a consequence of its use-dependent block. (en)
Title
  • Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments
  • Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments (en)
  • Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments (cs)
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  • Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments
  • Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments (en)
  • Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments (cs)
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  • RIV/00216224:14110/03:00008624!RIV09-GA0-14110___
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  • RIV/00216224:14110/03:00008624
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  • rate dependence; action potential; action potential voltage clamp; rat; ajmaline (en)
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  • [E8DD74A5619D]
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  • Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments
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  • Bébarová, Markéta
  • Pásek, Michal
  • Šimurda, Jiří
  • Šimurdová, Milena
  • Matejovič, Peter
http://linked.open...n/vavai/riv/zamer
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  • Neuveden
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  • 80-7013-394-5
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  • 14110
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