About: Arrhythmogenic effect of extracellular K-depletion is prevented by the transverse-axial tubular system in a ventricular cardiac cell model     Goto   Sponge   NotDistinct   Permalink

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  • In this work, we studied the role of the transverse-axial tubular system (TAT-system) in arrythmogenesis of ventricular cardiac cells under conditions of simulated hypokalaemia (low [K]e). We used the model of a mammalian ventricular myocyte that integrated the quantitative description of electrical activity of surface and tubular membranes and dynamic changes in intracellular ion concentrations. To maintain potassium homeostasis, an energy-dependent K+ extrusion pump was incorporated into the model. According to predictions provided by the model, the TAT-system protects the cell against arrhythmogenesis due to the enhancement of a potassium concentration gradient between tubular and extracellular spaces at low levels of [K]e. The energy-dependent K extrusion pump maintains tubular [K] at a level higher than the overall [K]e. This makes the activation of tubular K-conductances responsible for action potential repolarisation and resting voltage.
  • In this work, we studied the role of the transverse-axial tubular system (TAT-system) in arrythmogenesis of ventricular cardiac cells under conditions of simulated hypokalaemia (low [K]e). We used the model of a mammalian ventricular myocyte that integrated the quantitative description of electrical activity of surface and tubular membranes and dynamic changes in intracellular ion concentrations. To maintain potassium homeostasis, an energy-dependent K+ extrusion pump was incorporated into the model. According to predictions provided by the model, the TAT-system protects the cell against arrhythmogenesis due to the enhancement of a potassium concentration gradient between tubular and extracellular spaces at low levels of [K]e. The energy-dependent K extrusion pump maintains tubular [K] at a level higher than the overall [K]e. This makes the activation of tubular K-conductances responsible for action potential repolarisation and resting voltage. (en)
  • In this work, we studied the role of the transverse-axial tubular system (TAT-system) in arrythmogenesis of ventricular cardiac cells under conditions of simulated hypokalaemia (low [K]e). We used the model of a mammalian ventricular myocyte that integrated the quantitative description of electrical activity of surface and tubular membranes and dynamic changes in intracellular ion concentrations. To maintain potassium homeostasis, an energy-dependent K+ extrusion pump was incorporated into the model. According to predictions provided by the model, the TAT-system protects the cell against arrhythmogenesis due to the enhancement of a potassium concentration gradient between tubular and extracellular spaces at low levels of [K]e. The energy-dependent K extrusion pump maintains tubular [K] at a level higher than the overall [K]e. This makes the activation of tubular K-conductances responsible for action potential repolarisation and resting voltage. (cs)
Title
  • Arrhythmogenic effect of extracellular K-depletion is prevented by the transverse-axial tubular system in a ventricular cardiac cell model
  • Arrhythmogenic effect of extracellular K-depletion is prevented by the transverse-axial tubular system in a ventricular cardiac cell model (en)
  • Arrhythmogenic effect of extracellular K-depletion is prevented by the transverse-axial tubular system in a ventricular cardiac cell model (cs)
skos:prefLabel
  • Arrhythmogenic effect of extracellular K-depletion is prevented by the transverse-axial tubular system in a ventricular cardiac cell model
  • Arrhythmogenic effect of extracellular K-depletion is prevented by the transverse-axial tubular system in a ventricular cardiac cell model (en)
  • Arrhythmogenic effect of extracellular K-depletion is prevented by the transverse-axial tubular system in a ventricular cardiac cell model (cs)
skos:notation
  • RIV/00216224:14110/02:00007136!RIV08-MSM-14110___
http://linked.open.../vavai/riv/strany
  • 179
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GP204/02/D129), Z(AV0Z2076919), Z(MSM 141100004)
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 638989
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/02:00007136
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • ventricular cell; low external [K]; tubular system; quantitative modelling (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [4815A802E8AC]
http://linked.open...i/riv/nazevZdroje
  • Scripta Medica Fac.Med.Univ.Masaryk.Brun.
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 75
http://linked.open...iv/tvurceVysledku
  • Pásek, Michal
  • Šimurda, Jiří
  • Christé, Georges
http://linked.open...n/vavai/riv/zamer
issn
  • 1211-3395
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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