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  • The purpose of this study was to assess pharmacokinetics of dextromethorphan (model substrate of metabolism by CYP 450). Dextromethorphan was used as surrogate marker of CYP2D1 activity as it is preferentially metabolised via O-demethylation by CYP2D1 to its primary metabolite dextrorphan (DOR). CYP3A4 is responsible for N-demethylation of DEM to methoxymorphinan and of DOR to hydroxymorphinan. CYP2D1 is the homolog of human CYP2D6. Fluoxetine has been reported to be of therapeutic benefit in the treatment of alcoholism; it was the aim of the present study to compare the effect of fluoxetine (20mg/kg for 6 days i.p.)in the rats pretreated by methamphetamine (10mg/kg for 6 days i.p.), as well as to answer the question if fluoxetin may be used for the characterization of novel pharmacotherapy in methamphetamine dependence. Fluoxetine in our experiments inhibited metabolism by the CYP2D1 and the CYP3A4. Methamphetamine stimulated metabolism mediated by the CYP2D1 but not by the CYP3A4. Combination of dru
  • The purpose of this study was to assess pharmacokinetics of dextromethorphan (model substrate of metabolism by CYP 450). Dextromethorphan was used as surrogate marker of CYP2D1 activity as it is preferentially metabolised via O-demethylation by CYP2D1 to its primary metabolite dextrorphan (DOR). CYP3A4 is responsible for N-demethylation of DEM to methoxymorphinan and of DOR to hydroxymorphinan. CYP2D1 is the homolog of human CYP2D6. Fluoxetine has been reported to be of therapeutic benefit in the treatment of alcoholism; it was the aim of the present study to compare the effect of fluoxetine (20mg/kg for 6 days i.p.)in the rats pretreated by methamphetamine (10mg/kg for 6 days i.p.), as well as to answer the question if fluoxetin may be used for the characterization of novel pharmacotherapy in methamphetamine dependence. Fluoxetine in our experiments inhibited metabolism by the CYP2D1 and the CYP3A4. Methamphetamine stimulated metabolism mediated by the CYP2D1 but not by the CYP3A4. Combination of dru (en)
  • The purpose of this study was to assess pharmacokinetics of dextromethorphan (model substrate of metabolism by CYP 450). Dextromethorphan was used as surrogate marker of CYP2D1 activity as it is preferentially metabolised via O-demethylation by CYP2D1 to its primary metabolite dextrorphan (DOR). CYP3A4 is responsible for N-demethylation of DEM to methoxymorphinan and of DOR to hydroxymorphinan. CYP2D1 is the homolog of human CYP2D6. Fluoxetine has been reported to be of therapeutic benefit in the treatment of alcoholism; it was the aim of the present study to compare the effect of fluoxetine (20mg/kg for 6 days i.p.)in the rats pretreated by methamphetamine (10mg/kg for 6 days i.p.), as well as to answer the question if fluoxetin may be used for the characterization of novel pharmacotherapy in methamphetamine dependence. Fluoxetine in our experiments inhibited metabolism by the CYP2D1 and the CYP3A4. Methamphetamine stimulated metabolism mediated by the CYP2D1 but not by the CYP3A4. Combination of dru (cs)
Title
  • Pharmacokinetics of dextromethorphane in rats pretreated with methamphetamine and fluoxetine
  • Pharmacokinetics of dextromethorphane in rats pretreated with methamphetamine and fluoxetine (en)
  • Vliv ,etamfetaminu a fluoxetinu na farmakokinetiku dextrometorfanu (cs)
skos:prefLabel
  • Pharmacokinetics of dextromethorphane in rats pretreated with methamphetamine and fluoxetine
  • Pharmacokinetics of dextromethorphane in rats pretreated with methamphetamine and fluoxetine (en)
  • Vliv ,etamfetaminu a fluoxetinu na farmakokinetiku dextrometorfanu (cs)
skos:notation
  • RIV/00216224:14110/02:00006927!RIV08-MSM-14110___
http://linked.open.../vavai/riv/strany
  • 310-310
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM 141100001)
http://linked.open...iv/cisloPeriodika
  • 9
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 658117
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/02:00006927
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • dextromethorphane; fluoxetine; methamphetamine (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [C94427F3CA36]
http://linked.open...i/riv/nazevZdroje
  • Bratislavské lekárské listy
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 103
http://linked.open...iv/tvurceVysledku
  • Dostálek, Miroslav
  • Slíva, Jiří
  • Tomandl, Josef
  • McCaskey Hadašová, Eva
http://linked.open...n/vavai/riv/zamer
issn
  • 0006-9248
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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