| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - Methamphetamine acts neurotoxically in the brain, also on the serotonergic system, what is believed to endorse its behavioral effects and abuse. Thus, the present study ascertained the effects of 5-HT1A and 5-HT1B receptor ligands on intake of methamphetamine in rats with dependence raised in i. v. self-administration procedure (a fixed-ratio schedule: FR). Rats with stable methamphetamine intake on FR3 were acutely pretreated with serotonergics 15 minutes prior to self-administration session. The intraperitoneal pretreatment used: a) saline solution as a control (2.0 ml/kg, n=6), b) 5-HT1A/B agonist RU24969 (0.5; 1.5 and 4.5 mg/kg, n=13), c) 5-HT1A agonist 8-OH-DPAT (0.3; 1.0 and 3.0 mg/kg, n=6, d) 5-HT1B agonist CGS 12066B (1.0; 5.0 and 15.0 mg/kg, n=10). Statistical analysis was performed by the Wilcoxon matched-pairs signed-ranks test, two-tailed. Agonist of 5-HT1A receptor subtype had no significant influence on methamphetamine intake. The drug intake was partially suppressed by mixed 5-HT1A/B ag
- Methamphetamine acts neurotoxically in the brain, also on the serotonergic system, what is believed to endorse its behavioral effects and abuse. Thus, the present study ascertained the effects of 5-HT1A and 5-HT1B receptor ligands on intake of methamphetamine in rats with dependence raised in i. v. self-administration procedure (a fixed-ratio schedule: FR). Rats with stable methamphetamine intake on FR3 were acutely pretreated with serotonergics 15 minutes prior to self-administration session. The intraperitoneal pretreatment used: a) saline solution as a control (2.0 ml/kg, n=6), b) 5-HT1A/B agonist RU24969 (0.5; 1.5 and 4.5 mg/kg, n=13), c) 5-HT1A agonist 8-OH-DPAT (0.3; 1.0 and 3.0 mg/kg, n=6, d) 5-HT1B agonist CGS 12066B (1.0; 5.0 and 15.0 mg/kg, n=10). Statistical analysis was performed by the Wilcoxon matched-pairs signed-ranks test, two-tailed. Agonist of 5-HT1A receptor subtype had no significant influence on methamphetamine intake. The drug intake was partially suppressed by mixed 5-HT1A/B ag (en)
- Methamphetamine acts neurotoxically in the brain, also on the serotonergic system, what is believed to endorse its behavioral effects and abuse. Thus, the present study ascertained the effects of 5-HT1A and 5-HT1B receptor ligands on intake of methamphetamine in rats with dependence raised in i. v. self-administration procedure (a fixed-ratio schedule: FR). Rats with stable methamphetamine intake on FR3 were acutely pretreated with serotonergics 15 minutes prior to self-administration session. The intraperitoneal pretreatment used: a) saline solution as a control (2.0 ml/kg, n=6), b) 5-HT1A/B agonist RU24969 (0.5; 1.5 and 4.5 mg/kg, n=13), c) 5-HT1A agonist 8-OH-DPAT (0.3; 1.0 and 3.0 mg/kg, n=6, d) 5-HT1B agonist CGS 12066B (1.0; 5.0 and 15.0 mg/kg, n=10). Statistical analysis was performed by the Wilcoxon matched-pairs signed-ranks test, two-tailed. Agonist of 5-HT1A receptor subtype had no significant influence on methamphetamine intake. The drug intake was partially suppressed by mixed 5-HT1A/B ag (cs)
|
| Title
| - Involvement of 5-HT1A and 5-HT1B Receptors in Modulation of Methamphetamine I.V. Self-Administration in Rats
- Involvement of 5-HT1A and 5-HT1B Receptors in Modulation of Methamphetamine I.V. Self-Administration in Rats (en)
- Involvement of 5-HT1A and 5-HT1B Receptors in Modulation of Methamphetamine I.V. Self-Administration in Rats (cs)
|
| skos:prefLabel
| - Involvement of 5-HT1A and 5-HT1B Receptors in Modulation of Methamphetamine I.V. Self-Administration in Rats
- Involvement of 5-HT1A and 5-HT1B Receptors in Modulation of Methamphetamine I.V. Self-Administration in Rats (en)
- Involvement of 5-HT1A and 5-HT1B Receptors in Modulation of Methamphetamine I.V. Self-Administration in Rats (cs)
|
| skos:notation
| - RIV/00216224:14110/02:00006178!RIV08-MSM-14110___
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/02:00006178
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - methamphetamine; self-administration; 5-HT1A receptor; 5-HT1B receptor; rats (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...v/mistoKonaniAkce
| - 13. - 15. 6, 2002, Quebec, Canada
|
| http://linked.open...i/riv/mistoVydani
| |
| http://linked.open...i/riv/nazevZdroje
| - The 7th NIDA International Forum
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...iv/tvurceVysledku
| - Nováková, Jana
- Šulcová, Alexandra
- Vinklerová, Jana
|
| http://linked.open...vavai/riv/typAkce
| |
| http://linked.open.../riv/zahajeniAkce
| |
| http://linked.open...n/vavai/riv/zamer
| |
| number of pages
| |
| http://purl.org/ne...btex#hasPublisher
| - US National Institute on Drug Addiction (NIDA)
|
| http://localhost/t...ganizacniJednotka
| |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)