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| rdf:type
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| Description
| - We tested capabilities of drugs elevating extracellular adenosine and of granulocyte colony-stimulating, factor (G-CSF) given alone or in combination to modulate regeneration from severe myelosuppression resulting from combined exposure of mice to ionizing radiation and carboplatin. Elevation of extracellular adenosine was induced by joint administration of dipyridamole (DP), a drug inhibiting the cellular uptake of adenosine, and adenosine monophosphate (AMP), serving as an adenosine prodrug. DP+AMP, G-CSF or all these drugs in combination were administered in a 4-d treatment regimen starting on day 3 after induction of myelosuppression. Comparable enhancements of haematopoietic regeneration due to elevation of extracellular adenosine or to action of G-CSF were demonstrated as shown by elevated numbers of haematopoietic progenitor cells for granulocytes/macrophages (GM-CFC) and erythrocytes (BFU-E) in the bone marrow and spleen in early time intervals after termination of the drug treatment, i.e. on
- We tested capabilities of drugs elevating extracellular adenosine and of granulocyte colony-stimulating, factor (G-CSF) given alone or in combination to modulate regeneration from severe myelosuppression resulting from combined exposure of mice to ionizing radiation and carboplatin. Elevation of extracellular adenosine was induced by joint administration of dipyridamole (DP), a drug inhibiting the cellular uptake of adenosine, and adenosine monophosphate (AMP), serving as an adenosine prodrug. DP+AMP, G-CSF or all these drugs in combination were administered in a 4-d treatment regimen starting on day 3 after induction of myelosuppression. Comparable enhancements of haematopoietic regeneration due to elevation of extracellular adenosine or to action of G-CSF were demonstrated as shown by elevated numbers of haematopoietic progenitor cells for granulocytes/macrophages (GM-CFC) and erythrocytes (BFU-E) in the bone marrow and spleen in early time intervals after termination of the drug treatment, i.e. on (en)
- We tested capabilities of drugs elevating extracellular adenosine and of granulocyte colony-stimulating, factor (G-CSF) given alone or in combination to modulate regeneration from severe myelosuppression resulting from combined exposure of mice to ionizing radiation and carboplatin. Elevation of extracellular adenosine was induced by joint administration of dipyridamole (DP), a drug inhibiting the cellular uptake of adenosine, and adenosine monophosphate (AMP), serving as an adenosine prodrug. DP+AMP, G-CSF or all these drugs in combination were administered in a 4-d treatment regimen starting on day 3 after induction of myelosuppression. Comparable enhancements of haematopoietic regeneration due to elevation of extracellular adenosine or to action of G-CSF were demonstrated as shown by elevated numbers of haematopoietic progenitor cells for granulocytes/macrophages (GM-CFC) and erythrocytes (BFU-E) in the bone marrow and spleen in early time intervals after termination of the drug treatment, i.e. on (cs)
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| Title
| - Drugs elevating extracellular adenosine promote regeneration of haematopoietic progenitor cells in severely myeloosuppressed mice: their comparison and joint effects with the granulocyte colony-stimulating factor
- Drugs elevating extracellular adenosine promote regeneration of haematopoietic progenitor cells in severely myeloosuppressed mice: their comparison and joint effects with the granulocyte colony-stimulating factor (en)
- Drugs elevating extracellular adenosine promote regeneration of haematopoietic progenitor cells in severely myeloosuppressed mice: their comparison and joint effects with the granulocyte colony-stimulating factor (cs)
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| skos:prefLabel
| - Drugs elevating extracellular adenosine promote regeneration of haematopoietic progenitor cells in severely myeloosuppressed mice: their comparison and joint effects with the granulocyte colony-stimulating factor
- Drugs elevating extracellular adenosine promote regeneration of haematopoietic progenitor cells in severely myeloosuppressed mice: their comparison and joint effects with the granulocyte colony-stimulating factor (en)
- Drugs elevating extracellular adenosine promote regeneration of haematopoietic progenitor cells in severely myeloosuppressed mice: their comparison and joint effects with the granulocyte colony-stimulating factor (cs)
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| skos:notation
| - RIV/00216224:14110/02:00005822!RIV08-GA0-14110___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/02:00005822
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - extracellular adenosine; dipyridamole; adenosine monophosphate; G-CSF; ionizing radiation; cytostatic drugs; myelosuppression (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - European Journal of Haematology
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Hofer, Michal
- Pospíšil, Milan
- Weiterová, Lenka
- Vacek, Antonín
- Holá, Jiřina
- Znojil, Vladimír
- Vácha, Jiří
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
| |
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