About: Association of three polymorphisms in the gene coding for endothelin-1 (ET-1) with the essential hypertension, overweight and smoking.

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About: Association of three polymorphisms in the gene coding for endothelin-1 (ET-1) with the essential hypertension, overweight and smoking. Goto Sponge NotDistinct Permalink

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Description	The aim of the study is to evaluate association of three endothelin-1 (ET-1) gene polymorphisms with the essential hypertension as well as with two risk cardiovascular factors- BMI and smoking. Three gene polymorphisms and the genotype and/or allelic distributions were compared between normotensive healthy volunteers and patients with essential hypertension. Genetic association of the three genotypes with BMI and smoking status was calculated. CA/CT dinucleotide repeat polymorphism, the G (8002) A polymorphism and 3A/-4A polymorphism (-138 insertion/ deletion) in the gene coding for endothelin-1 (ET-1, 6p21.3) in 398 subjects, 192 normotensives (healthy volunteers) and 206 patients with essential hypertension. The normotension was verified by 24-h ambulatory blood pressure monitoring (ABPM, SpaceLab 90 207). Significant inner associations were observed among all three polymophisms, which suggests possible complex interaction inside the gene. The only significant difference in single gene case-contro The aim of the study is to evaluate association of three endothelin-1 (ET-1) gene polymorphisms with the essential hypertension as well as with two risk cardiovascular factors- BMI and smoking. Three gene polymorphisms and the genotype and/or allelic distributions were compared between normotensive healthy volunteers and patients with essential hypertension. Genetic association of the three genotypes with BMI and smoking status was calculated. CA/CT dinucleotide repeat polymorphism, the G (8002) A polymorphism and 3A/-4A polymorphism (-138 insertion/ deletion) in the gene coding for endothelin-1 (ET-1, 6p21.3) in 398 subjects, 192 normotensives (healthy volunteers) and 206 patients with essential hypertension. The normotension was verified by 24-h ambulatory blood pressure monitoring (ABPM, SpaceLab 90 207). Significant inner associations were observed among all three polymophisms, which suggests possible complex interaction inside the gene. The only significant difference in single gene case-contro (en)
Title	Association of three polymorphisms in the gene coding for endothelin-1 (ET-1) with the essential hypertension, overweight and smoking. Association of three polymorphisms in the gene coding for endothelin-1 (ET-1) with the essential hypertension, overweight and smoking. (en)
skos:prefLabel	Association of three polymorphisms in the gene coding for endothelin-1 (ET-1) with the essential hypertension, overweight and smoking. Association of three polymorphisms in the gene coding for endothelin-1 (ET-1) with the essential hypertension, overweight and smoking. (en)
skos:notation	RIV/00216224:14110/02:00005720!RIV/2003/MSM/141103/N
http://linked.open.../vavai/riv/strany	xxx
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 141100002)
http://linked.open...iv/cisloPeriodika	xx
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Mužík, Jan Vašků, Anna Tschöplová, Svatava Vácha, Jiří Souček, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	639082
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/02:00005720
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	endothelin-1, gene polymorphism, essential hypertension, BMI, smoking (en)
http://linked.open.../riv/klicoveSlovo	BMI gene polymorphism smoking - drinking alcohol - students of the University of South Bohemia - preventive programmes essential hypertension endothelin-1
http://linked.open...odStatuVydavatele	CA - Kanada
http://linked.open...ontrolniKodProRIV	[31BF0C14C44C]
http://linked.open...i/riv/nazevZdroje	Experimental and Clinical Cardiology
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
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http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	2002
http://linked.open...iv/tvurceVysledku	Souček, Miroslav Vašků, Anna Mužík, Jan Tschöplová, Svatava Vácha, Jiří
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20141100002
number of pages	5 (xsd:int)
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