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| Description
| - Background: The study was designed to investigate the associations among polymorphisms TNF-b NcoI and TNF-a -308G/A, plasma TNF-a levels and metabolic and anthropometric parameters related to insulin sensitivity in a set of 113 Caucasian subjects undergoing oral glucose tolerance test (oGTT). Methods: Genotypes were detected by PCR; BMI, WHR, glycemia during oGTT, fasting immunoreactive insulin, fasting C-peptide, HbA1c, total cholesterol, triglycerides, HDL, LDL and plasma TNF-a levels were measured in each subject. Results: Type 2 diabetes was diagnosed in 10 subjects, impaired glucose tolerance (IGT) in 41, normal glucose tolerance (NGT) in 62. Significant differences among genotypes of the TNF-b NcoI were observed for FPG (P=0.0063), LDL (P=0.0179) and marginally for total cholesterol (P=0.0763) in NGT group. After the classification of NGT subjects into obese and non-obese according to BMI, associations of TNF-b NcoI with FPG, LDL and cholesterol were proved in non-obese subgroup only. TNF-a -308
- Background: The study was designed to investigate the associations among polymorphisms TNF-b NcoI and TNF-a -308G/A, plasma TNF-a levels and metabolic and anthropometric parameters related to insulin sensitivity in a set of 113 Caucasian subjects undergoing oral glucose tolerance test (oGTT). Methods: Genotypes were detected by PCR; BMI, WHR, glycemia during oGTT, fasting immunoreactive insulin, fasting C-peptide, HbA1c, total cholesterol, triglycerides, HDL, LDL and plasma TNF-a levels were measured in each subject. Results: Type 2 diabetes was diagnosed in 10 subjects, impaired glucose tolerance (IGT) in 41, normal glucose tolerance (NGT) in 62. Significant differences among genotypes of the TNF-b NcoI were observed for FPG (P=0.0063), LDL (P=0.0179) and marginally for total cholesterol (P=0.0763) in NGT group. After the classification of NGT subjects into obese and non-obese according to BMI, associations of TNF-b NcoI with FPG, LDL and cholesterol were proved in non-obese subgroup only. TNF-a -308 (en)
- Zjistili jsme, ze polymorfizmus NcoI v genu pro tumornekrotizujici faktor b je asociovan s glykemii nalacno a lipidovymi parametry (LDL a cholesterol) u zdravych neobeznich osob. (cs)
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| Title
| - Polymorfizmus NcoI v genu pro tumornekrotizujici faktor b je asociovan s glykemii nalacno a lipidovymi parametry u zdravych neobeznich osob: predbezne vysledky (cs)
- Polymorphism NcoI in tumor necrosis factor b is associated with fasting glycemia and lipid parameters in healthy non-obese Caucasian subjects: Preliminary report
- Polymorphism NcoI in tumor necrosis factor b is associated with fasting glycemia and lipid parameters in healthy non-obese Caucasian subjects: Preliminary report (en)
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| skos:prefLabel
| - Polymorfizmus NcoI v genu pro tumornekrotizujici faktor b je asociovan s glykemii nalacno a lipidovymi parametry u zdravych neobeznich osob: predbezne vysledky (cs)
- Polymorphism NcoI in tumor necrosis factor b is associated with fasting glycemia and lipid parameters in healthy non-obese Caucasian subjects: Preliminary report
- Polymorphism NcoI in tumor necrosis factor b is associated with fasting glycemia and lipid parameters in healthy non-obese Caucasian subjects: Preliminary report (en)
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| skos:notation
| - RIV/00216224:14110/02:00005552!RIV09-MSM-14110___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/02:00005552
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Type 2 diabetes mellitus; TNF-b polymorphism; insulin resistance; glycemia; glucose intolerance (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - FR - Francouzská republika
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Jurajda, Michal
- Márová, Ivana
- Vašků, Anna
- Kaňková, Kateřina
- Vácha, Jiří
- Jansen, Eugene H. J. M.
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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