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  • Common variable immunodeficiency (CVID) and IgA deficiency (IgAD) are primary humoral immune deficiencies with probably similar genetic background, but clinical and laboratory manifestation is much more severe in CVID than in IgAD. The aim of this study was to determine whether some abnormalities in T-lymphocyte subsets or function previously observed in CVID are also present in IgAD patients. T-lymphocyte subsets (CD3, CD4, CD8, CD4CD45RA, CD4CD45RO, CD8CD57) were studied in 61 adult IgAD patients and 43 control healthy persons. A significant decrease in CD4+ and increase in CD8+ and CD8+CD57+ lymphocytes was observed, while no significant changes in the proportion of CD45RA+ or CD45RO+ in CD4 cells were detected. No significant changes in lymphocyte proliferation after stimulation with Phytohaemagglutinin, Concanavalin-A or tetanic toxoid were observed in 15 adult IgAD patients compared to 15 controls. Our study shows, that T-lymphocyte abnormalities are also present in IgAD patient, although not i
  • Common variable immunodeficiency (CVID) and IgA deficiency (IgAD) are primary humoral immune deficiencies with probably similar genetic background, but clinical and laboratory manifestation is much more severe in CVID than in IgAD. The aim of this study was to determine whether some abnormalities in T-lymphocyte subsets or function previously observed in CVID are also present in IgAD patients. T-lymphocyte subsets (CD3, CD4, CD8, CD4CD45RA, CD4CD45RO, CD8CD57) were studied in 61 adult IgAD patients and 43 control healthy persons. A significant decrease in CD4+ and increase in CD8+ and CD8+CD57+ lymphocytes was observed, while no significant changes in the proportion of CD45RA+ or CD45RO+ in CD4 cells were detected. No significant changes in lymphocyte proliferation after stimulation with Phytohaemagglutinin, Concanavalin-A or tetanic toxoid were observed in 15 adult IgAD patients compared to 15 controls. Our study shows, that T-lymphocyte abnormalities are also present in IgAD patient, although not i (en)
Title
  • T-lymphocyte subsets and function in IgA deficiency
  • T-lymphocyte subsets and function in IgA deficiency (en)
skos:prefLabel
  • T-lymphocyte subsets and function in IgA deficiency
  • T-lymphocyte subsets and function in IgA deficiency (en)
skos:notation
  • RIV/00216224:14110/01:00006090!RIV/2003/MZ0/141103/N
http://linked.open.../vavai/riv/strany
  • 345
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  • P(NI4703)
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  • 5
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  • 698864
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  • RIV/00216224:14110/01:00006090
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  • IgA deficiency, T-lymphocytes, lymphocyte subsets (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [5B348438427A]
http://linked.open...i/riv/nazevZdroje
  • Scripta Medica
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 74
http://linked.open...iv/tvurceVysledku
  • Litzman, Jiří
  • Lokaj, Jindřich
  • Thon, Vojtěch
  • Štouračová, Martina
  • Krejčí, Marcela
issn
  • 1211-3395
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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