About: Some epidemiologic, pathogenetic and clinical aspects of selective IgA deficiency     Goto   Sponge   NotDistinct   Permalink

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Description
  • Jsou popsány nejdůležitější patogenetické faktory a klinická manifestace deficitu IgA.
  • Jsou popsány nejdůležitější patogenetické faktory a klinická manifestace deficitu IgA. (cs)
  • Despite its high frequency (1:408 in the Czech population), selective IgA deficiency ( IgAD) still remains an immunopathological state with many unresolved questions. Although a genetic linkage to non-aspartic acid residue on 57th position of HLA-DQ chain and frequent familiar occurrence is well documented, the real genetic basis is not known; a defect of genes of alpha heavy chains is not a cause. Very little is known about the etiopathogenesis of IgAD, probably different mechanisms may be involved in various affected persons. From the clinical point of view, IgAD is usually without clinical symptoms, but in some IgAD deficient persons proneness to frequent respiratory tract infections can be observed, namely in infancy and childhood. Also systemic and organ-specific autoimmune diseases are more frequent in IgAD persons than in general population. A clear association with allergic disorders was not documented. It is important to consider a danger of development of anti-IgA antibodies after administra (en)
Title
  • Some epidemiologic, pathogenetic and clinical aspects of selective IgA deficiency (en)
  • Některé epidemiologické, patogenetické a klinické aspekty selektivního deficitu IgA
  • Některé epidemiologické, patogenetické a klinické aspekty selektivního deficitu IgA (cs)
skos:prefLabel
  • Some epidemiologic, pathogenetic and clinical aspects of selective IgA deficiency (en)
  • Některé epidemiologické, patogenetické a klinické aspekty selektivního deficitu IgA
  • Některé epidemiologické, patogenetické a klinické aspekty selektivního deficitu IgA (cs)
skos:notation
  • RIV/00216224:14110/01:00005523!RIV09-MZ0-14110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NI4703), P(NI5220), P(NI5558)
http://linked.open...iv/cisloPeriodika
  • 4
http://linked.open...vai/riv/dodaniDat
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http://linked.open...iv/duvernostUdaju
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http://linked.open...dnocenehoVysledku
  • 688524
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14110/01:00005523
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • IgA deficiency; common variable deficiency; respiratory tract infections; autoimmune diseases (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [7DBFF6FA2D0C]
http://linked.open...i/riv/nazevZdroje
  • Alergie
http://linked.open...in/vavai/riv/obor
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 3
http://linked.open...iv/tvurceVysledku
  • Litzman, Jiří
issn
  • 1212-3536
number of pages
http://localhost/t...ganizacniJednotka
  • 14110
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