About: Polymorphisms in angiotensinogen gene (M235T and G/-6/A) in multifactorial diseases.

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About: Polymorphisms in angiotensinogen gene (M235T and G/-6/A) in multifactorial diseases. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of the study is to compare results of three association (case-control) studies in three multifactorial disorders (essential hypertension, atopic diseases and psoriasis) with two polymorphisms of angiotensinogen gene (M235T and A(-6)G AGT). The diseases were chosen for their multigenic base and different immunological characteristic (Th1, Th2 and Thps) and angiotensinogen gene for its pleiotropic functional effects in general adaptive reactions. In all (control as well as case) groups, tight linkage disequilibrium between the polymorphisms was found. The strength of linkage (%) differed among the group. The direction of the linkage is identical in all groups (T is combined with A, M is combined with G). In hypertensive-normotensive study, only Hardy-Weinberg disequilibria were found, especially in men. No case-control differences were found for either single alleles or for allelic concurrence of both polymorphisms. In atopy-control study, marginal case-control differences in The aim of the study is to compare results of three association (case-control) studies in three multifactorial disorders (essential hypertension, atopic diseases and psoriasis) with two polymorphisms of angiotensinogen gene (M235T and A(-6)G AGT). The diseases were chosen for their multigenic base and different immunological characteristic (Th1, Th2 and Thps) and angiotensinogen gene for its pleiotropic functional effects in general adaptive reactions. In all (control as well as case) groups, tight linkage disequilibrium between the polymorphisms was found. The strength of linkage (%) differed among the group. The direction of the linkage is identical in all groups (T is combined with A, M is combined with G). In hypertensive-normotensive study, only Hardy-Weinberg disequilibria were found, especially in men. No case-control differences were found for either single alleles or for allelic concurrence of both polymorphisms. In atopy-control study, marginal case-control differences in (en)
Title	Polymorphisms in angiotensinogen gene (M235T and G/-6/A) in multifactorial diseases. Polymorphisms in angiotensinogen gene (M235T and G/-6/A) in multifactorial diseases. (en)
skos:prefLabel	Polymorphisms in angiotensinogen gene (M235T and G/-6/A) in multifactorial diseases. Polymorphisms in angiotensinogen gene (M235T and G/-6/A) in multifactorial diseases. (en)
skos:notation	RIV/00216224:14110/01:00005187!RIV/2002/GA0/141102/N
http://linked.open.../vavai/riv/strany	113
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA306/93/2192), P(GA306/96/0099), Z(MSM 141100002)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2002
http://linked.open...aciTvurceVysledku	Izakovičová-Hollá, Lydie Vašků, Anna Tschöplová, Svatava Stejskalová, Andrea Vašků, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	691666
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/01:00005187
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Polymorphisms in angiotensinogen gene (M235T and G/-6/A) in multifactorial diseases. (en)
http://linked.open.../riv/klicoveSlovo	Polymorphisms in angiotensinogen gene (M235T and G/-6/A) in multifactorial diseases.
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[3A18F42AD0D2]
http://linked.open...i/riv/nazevZdroje	Pathophysiology
http://linked.open...in/vavai/riv/obor	FE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Polymorphisms of Genes Coding for Angiotensinogen and Angiotensin I Convertase in Essential Hypertension Polymorphism of endothelin - 1 gene (EDN 1) in essential hypertension
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	2001
http://linked.open...iv/tvurceVysledku	Vašků, Anna Vašků, Vladimír Tschöplová, Svatava Stejskalová, Andrea Izakovičová-Hollá, Lýdie
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20141100002
issn	0928-4680
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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