About: Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells.

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A mathematical model of the interaction of propafenone with sodium channels is based on experimental data that demonstrate use dependent effect of the drug. Transitions among channel states are described by a kinetic diagram and a corre-sponding set of differential equations. The values of rate constants of the drug-receptor reaction are fitted to experimental data by repeated computer simulations using a genetic algorithm. The model suggests the following interpretation of the obtained experimental results: 1) The affinity of the drug to its binding site is high in the open and inactivated states while it is low in the resting state. 2) The biphasic development of the block during depolarization is consistent with a high association rate constant in the open state and a lower one in the inactivated state. 3) The observed double exponential time course of recovery of INa at resting voltage after depolarizing pulse may result from concurrent drug release from inactivated and non-inactivated blocked cha A mathematical model of the interaction of propafenone with sodium channels is based on experimental data that demonstrate use dependent effect of the drug. Transitions among channel states are described by a kinetic diagram and a corre-sponding set of differential equations. The values of rate constants of the drug-receptor reaction are fitted to experimental data by repeated computer simulations using a genetic algorithm. The model suggests the following interpretation of the obtained experimental results: 1) The affinity of the drug to its binding site is high in the open and inactivated states while it is low in the resting state. 2) The biphasic development of the block during depolarization is consistent with a high association rate constant in the open state and a lower one in the inactivated state. 3) The observed double exponential time course of recovery of INa at resting voltage after depolarizing pulse may result from concurrent drug release from inactivated and non-inactivated blocked cha (en) A mathematical model of the interaction of propafenone with sodium channels is based on experimental data that demonstrate use dependent effect of the drug. Transitions among channel states are described by a kinetic diagram and a corre-sponding set of differential equations. The values of rate constants of the drug-receptor reaction are fitted to experimental data by repeated computer simulations using a genetic algorithm. The model suggests the following interpretation of the obtained experimental results: 1) The affinity of the drug to its binding site is high in the open and inactivated states while it is low in the resting state. 2) The biphasic development of the block during depolarization is consistent with a high association rate constant in the open state and a lower one in the inactivated state. 3) The observed double exponential time course of recovery of INa at resting voltage after depolarizing pulse may result from concurrent drug release from inactivated and non-inactivated blocked cha (cs)
Title	Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells. Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells. (en) Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells. (cs)
skos:prefLabel	Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells. Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells. (en) Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells. (cs)
skos:notation	RIV/00216224:14110/01:00005060!RIV09-MSM-14110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z2076919), Z(MSM 141100004)
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Pásek, Michal Šimurda, Jiří
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	693785
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/01:00005060
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cardiac cell; propafenone; quantitative modelling (en)
http://linked.open.../riv/klicoveSlovo	cardiac cell quantitative modelling propafenone
http://linked.open...ontrolniKodProRIV	[7883FB5B3F63]
http://linked.open...v/mistoKonaniAkce	12-15.6.2001 Pula (Croatia)
http://linked.open...i/riv/mistoVydani	Pula (Croatia)
http://linked.open...i/riv/nazevZdroje	Proceedings of the International Federation for Medical and Biologocal Engineering
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...UplatneniVysledku	2001
http://linked.open...iv/tvurceVysledku	Pásek, Michal Šimurda, Jiří
http://linked.open...vavai/riv/typAkce	CST - Celostátní
http://linked.open...ain/vavai/riv/wos	000176065600281
http://linked.open.../riv/zahajeniAkce	2001-01-01 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Dynamics of fluids, solids and their interactions http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20141100004
number of pages	4 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Faculty of Electrical Engineering, Zagreb
https://schema.org/isbn	953-184-024-5
http://localhost/t...ganizacniJednotka	14110

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