About: Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population

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About: Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Increased plasma concentration of homocysteine has been found in patients with coronary artery disease, essential hypertension and in patients with diabetic complications. The 677C/T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism is related to the MTHFR enzyme activity and to the plasma homocysteine concentration. This study was designed to investigate an association of this polymorphism with CAD, EH and type II diabetes mellitus in Czech population. The C allele of the 677C/T MTHFR polymorphism was associated with type II diabetes mellitus in women, the T allele was associated with CAD only in normotensive subjects of Czech origin. Increased plasma concentration of homocysteine has been found in patients with coronary artery disease, essential hypertension and in patients with diabetic complications. The 677C/T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism is related to the MTHFR enzyme activity and to the plasma homocysteine concentration. This study was designed to investigate an association of this polymorphism with CAD, EH and type II diabetes mellitus in Czech population. The C allele of the 677C/T MTHFR polymorphism was associated with type II diabetes mellitus in women, the T allele was associated with CAD only in normotensive subjects of Czech origin. (en) Studovali jsme asociaci polymorfizmu v methylenetetrahydrofolatreduktaze (MTHFR) s diabetem 2. typu, ICHS a esencialni hypertenzi v Ceske populaci. (cs)
Title	Polymorfizmus v methylenetetrahydrofolatreduktaze, diabetes mellitus 2. typu, ICHS a esencialni hypertenze v Ceske populaci (cs) Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population (en)
skos:prefLabel	Polymorfizmus v methylenetetrahydrofolatreduktaze, diabetes mellitus 2. typu, ICHS a esencialni hypertenze v Ceske populaci (cs) Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population (en)
skos:notation	RIV/00216224:14110/01:00004148!RIV09-MSM-14110___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 141100002)
http://linked.open...iv/cisloPeriodika	73
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Izakovičová-Hollá, Lydie Mužík, Jan Elbl, Lubomír Vašků, Anna Vácha, Jiří Groch, Ladislav Beneš, Petr Kaňková, Kateřina Znojil, Vladimír Benedík, Jaroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	686653
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/01:00004148
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	gene; polymorphism; MTHFR; CAD; hypertension; diabetes (en)
http://linked.open.../riv/klicoveSlovo	CAD MTHFR gene hypertension - ischaemic heart disease - cardiac failure - vitamin D polymorphism diabetes
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[7C2D3CAE2406]
http://linked.open...i/riv/nazevZdroje	Molecular Genetics and Metabolism
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	10 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	2
http://linked.open...iv/tvurceVysledku	Beneš, Petr Groch, Ladislav Izakovičová-Hollá, Lydie Vašků, Anna Mužík, Jan Kaňková, Kateřina Elbl, Lubomír Znojil, Vladimír Vácha, Jiří Benedík, Jaroslav
http://linked.open...ain/vavai/riv/wos	000169323700009
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20141100002
issn	1096-7192
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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