About: Duration of NIDDM and the TNFb NcoI genotype as predictive factors in proliferative diabetic retinopathy

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About: Duration of NIDDM and the TNFb NcoI genotype as predictive factors in proliferative diabetic retinopathy Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The object of the study was to investigate the share of polymorphisms I/D ACE, endothelin-1 4127G/A and TNFb NcoI in the susceptibility to proliferative diabetic retinopathy (PDR) in non-insulin dependent diabetes mellitus (NIDDM). Genotypes were detected by polymerase chain reactions and determined in a set of 246 Caucasian NIDDM subjects with defined PDR status. The relevance of genotypes and clinical characteristics to the PDR occurrence was tested using multiple linear regression models and discrimination analysis. The best predictive value for PDR was given by a combination of two parameters - NIDDM duration and the TNFb genotype (P<110-6 and P=110-2, respectively) with a correct retrograde prediction of 82.6%. A comparison of the TNFb NcoI allele frequencies revealed no difference between NIDDM and nondiabetic subjects (n=176), but a statistically significant difference was found between PDR and non-PDR NIDDM subjects (after a correction for the number of comparisons P=0.03); allele b2 being The object of the study was to investigate the share of polymorphisms I/D ACE, endothelin-1 4127G/A and TNFb NcoI in the susceptibility to proliferative diabetic retinopathy (PDR) in non-insulin dependent diabetes mellitus (NIDDM). Genotypes were detected by polymerase chain reactions and determined in a set of 246 Caucasian NIDDM subjects with defined PDR status. The relevance of genotypes and clinical characteristics to the PDR occurrence was tested using multiple linear regression models and discrimination analysis. The best predictive value for PDR was given by a combination of two parameters - NIDDM duration and the TNFb genotype (P<110-6 and P=110-2, respectively) with a correct retrograde prediction of 82.6%. A comparison of the TNFb NcoI allele frequencies revealed no difference between NIDDM and nondiabetic subjects (n=176), but a statistically significant difference was found between PDR and non-PDR NIDDM subjects (after a correction for the number of comparisons P=0.03); allele b2 being (en)
Title	Duration of NIDDM and the TNFb NcoI genotype as predictive factors in proliferative diabetic retinopathy Duration of NIDDM and the TNFb NcoI genotype as predictive factors in proliferative diabetic retinopathy (en)
skos:prefLabel	Duration of NIDDM and the TNFb NcoI genotype as predictive factors in proliferative diabetic retinopathy Duration of NIDDM and the TNFb NcoI genotype as predictive factors in proliferative diabetic retinopathy (en)
skos:notation	RIV/00216224:14110/01:00002752!RIV/2002/MSM/141102/N
http://linked.open.../vavai/riv/strany	294
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(VS96097), Z(MSM 141100002)
http://linked.open...iv/cisloPeriodika	215
http://linked.open...vai/riv/dodaniDat	2002
http://linked.open...aciTvurceVysledku	Hájek, Dobroslav Mužík, Jan Vlková, Eva Beránek, Michal Vácha, Jiří Kaňková, Kateřina Znojil, Vladimír Karásková, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	678308
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/01:00002752
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Duration of NIDDM and the TNFb NcoI genotype as predictive factors in proliferative diabetic retinopathy (en)
http://linked.open.../riv/klicoveSlovo	Duration of NIDDM and the TNFb NcoI genotype as predictive factors in proliferative diabetic retinopathy
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[91B86140AFFF]
http://linked.open...i/riv/nazevZdroje	Ophthalmologica
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular pathophysiology of selected multigenic related to civilization diseases
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	4
http://linked.open...iv/tvurceVysledku	Mužík, Jan Vlková, Eva Kaňková, Kateřina Beránek, Michal Znojil, Vladimír Hájek, Dobroslav Vácha, Jiří Karásková, Jana
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20141100002
issn	0030-3755
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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