About: IgA deficincy in Czech healthy individuals and selected patient groups

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background: Selective IgA deficiency (IgAD) is the most common immunoglobulin deficiency with a variety of clinical manifestations. The frequency of IgAD differs depending on ethnic origin and clinical symptoms of investigated persons. Methods: The prevalence of IgAD (serum IgA level < 0.05 g/l) was determined in 5310 Czech blood donors, 10 326 patients underwent immunological investigation, and in 246 first degree -relatives of IgA deficient and common variable immunodeficiency (CVID) patients. Results: Selective IgA deficiency was detected in 13 (1: 408; 0.24%) of the blood donors. The prevalence of IgAD was increased both in children (48/3113; 1.5%) and adults (33/3824; 0.9%) referred for frequent respiratory tract infections (in both cases P< 0.001) compared to the healthy population. The frequency of IgAD was 12/189 (6%) in first degree relatives of IgAD patients, and 9/57 (16%) in relatives of CVID patients, with the highest frequency observed in children of CVID patients. Conclusions: The Background: Selective IgA deficiency (IgAD) is the most common immunoglobulin deficiency with a variety of clinical manifestations. The frequency of IgAD differs depending on ethnic origin and clinical symptoms of investigated persons. Methods: The prevalence of IgAD (serum IgA level < 0.05 g/l) was determined in 5310 Czech blood donors, 10 326 patients underwent immunological investigation, and in 246 first degree -relatives of IgA deficient and common variable immunodeficiency (CVID) patients. Results: Selective IgA deficiency was detected in 13 (1: 408; 0.24%) of the blood donors. The prevalence of IgAD was increased both in children (48/3113; 1.5%) and adults (33/3824; 0.9%) referred for frequent respiratory tract infections (in both cases P< 0.001) compared to the healthy population. The frequency of IgAD was 12/189 (6%) in first degree relatives of IgAD patients, and 9/57 (16%) in relatives of CVID patients, with the highest frequency observed in children of CVID patients. Conclusions: The (en)
Title	IgA deficincy in Czech healthy individuals and selected patient groups IgA deficincy in Czech healthy individuals and selected patient groups (en)
skos:prefLabel	IgA deficincy in Czech healthy individuals and selected patient groups IgA deficincy in Czech healthy individuals and selected patient groups (en)
skos:notation	RIV/00216224:14110/00:00003660!RIV/2002/MZ0/141102/N
http://linked.open.../vavai/riv/strany	177
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NI4703)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2002
http://linked.open...aciTvurceVysledku	Lokaj, Jindřich Litzman, Jiří Pazdírková, Alexandra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	713116
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/00:00003660
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	IgA deficiency, common variable immunodeficiency, repiratory tract infections (en)
http://linked.open.../riv/klicoveSlovo	IgA deficiency common variable immunodeficiency repiratory tract infections
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[31703F2F58A6]
http://linked.open...i/riv/nazevZdroje	Int Arch Allergy Immunol
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Immunoregulatory defects in patients with humoral immunodeficiencies
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	123
http://linked.open...iv/tvurceVysledku	Litzman, Jiří Lokaj, Jindřich Štikarovská, Dagmar Ševčíková, Irena Pazdírková, Alexandra Pikulová, Zdena
issn	1018-2438
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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