About: Influence of selected SSRI on activity of cytochrome P450 2D1 and arylamine N-acetyltransferase in Wistar rats [Vliv vybraných SSRI na aktivitu cytochromu P450 2D1 a arylamin-N-acetyltransferázy u potkanů Wistar]

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About: Influence of selected SSRI on activity of cytochrome P450 2D1 and arylamine N-acetyltransferase in Wistar rats [Vliv vybraných SSRI na aktivitu cytochromu P450 2D1 a arylamin-N-acetyltransferázy u potkanů Wistar] Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The study was undertaken to characterize changes of the activities of oxidative and conjugative hepatic enzymes, CYP2D1 and NAT2, induced by pretreatment with fluoxetine or paroxetine. Method of the isolated perfused liver from the male Wistar rat donors pretreated in vivo with SSRIs was used for the study. The results showed that the metabolic capacity of the liver for O-demethylation of dextromethorphane to dextrorphan was significantly decreased. Pretreatment with fluoxetine, but not with paroxetine, evoked also inhibition of activity of NAT2. Thus, SSRIs showed significant inhibitory effects upon the enzyme activities in the rat liver. The study was undertaken to characterize changes of the activities of oxidative and conjugative hepatic enzymes, CYP2D1 and NAT2, induced by pretreatment with fluoxetine or paroxetine. Method of the isolated perfused liver from the male Wistar rat donors pretreated in vivo with SSRIs was used for the study. The results showed that the metabolic capacity of the liver for O-demethylation of dextromethorphane to dextrorphan was significantly decreased. Pretreatment with fluoxetine, but not with paroxetine, evoked also inhibition of activity of NAT2. Thus, SSRIs showed significant inhibitory effects upon the enzyme activities in the rat liver. (en)
Title	Influence of selected SSRI on activity of cytochrome P450 2D1 and arylamine N-acetyltransferase in Wistar rats [Vliv vybraných SSRI na aktivitu cytochromu P450 2D1 a arylamin-N-acetyltransferázy u potkanů Wistar] Influence of selected SSRI on activity of cytochrome P450 2D1 and arylamine N-acetyltransferase in Wistar rats [Vliv vybraných SSRI na aktivitu cytochromu P450 2D1 a arylamin-N-acetyltransferázy u potkanů Wistar] (en)
skos:prefLabel	Influence of selected SSRI on activity of cytochrome P450 2D1 and arylamine N-acetyltransferase in Wistar rats [Vliv vybraných SSRI na aktivitu cytochromu P450 2D1 a arylamin-N-acetyltransferázy u potkanů Wistar] Influence of selected SSRI on activity of cytochrome P450 2D1 and arylamine N-acetyltransferase in Wistar rats [Vliv vybraných SSRI na aktivitu cytochromu P450 2D1 a arylamin-N-acetyltransferázy u potkanů Wistar] (en)
skos:notation	RIV/00216224:14110/00:00003135!RIV/2002/MSM/141102/N
http://linked.open.../vavai/riv/strany	384
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 141100001)
http://linked.open...iv/cisloPeriodika	15
http://linked.open...vai/riv/dodaniDat	2002
http://linked.open...aciTvurceVysledku	Nerušilová, Kateřina Charvátová, Zuzana McCaskey Hadašová, Eva Tomandlová, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	713566
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/00:00003135
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	SSRI; cytochrome P450 2D; arylamine-N-acetyltransferase; rat. (en)
http://linked.open.../riv/klicoveSlovo	SSRI arylamine-N-acetyltransferase cytochrome P450 2D rat.
http://linked.open...odStatuVydavatele	FR - Francouzská republika
http://linked.open...ontrolniKodProRIV	[D36492693E2A]
http://linked.open...i/riv/nazevZdroje	European psychiatry
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...UplatneniVysledku	2000
http://linked.open...v/svazekPeriodika	2000
http://linked.open...iv/tvurceVysledku	Tomandlová, Marie Hadašová, Eva Nerušilová, Kateřina Justinová, Zuzana
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20141100001
issn	0924-9338
number of pages	2 (xsd:int)
http://localhost/t...ganizacniJednotka	14110

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