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rdf:type
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Description
| - Four hundred of Caucasian (Czech) normotensive (normotension was confirmed by 24-h ambulatory blood pressure monitoring) and hypertensive subjects of the age of 45-55 years were compared in three ET-1 gene (6p21.3) polymorphisms CA/CT dinucleotide repeat in Z-area, I/D (-4A/-3A) polymorphism in the promoter and Taq1 (G8002A) polymorphism in the intron 4 detected by PCR methods.The allelic length of CA/CT dinucleotide repeat polymorphism was significantly higher in hypertensive subjects (P=0.032). Allelic concurrence of I/D promoter polymorphism and Taq1 polymorphism was significantly different (P=0.008) in hypertensive vs.normotensive women (not in men). Linkage disequilibria between CA/CT and Taq polymorphisms were found both in hypertensive (P=0.008) and normotensive (P=0.02) subjects. Complex interaction among alleles inside the gene coding for ET-1 gene could participate in pathogenesis of essential hypertension.
- Four hundred of Caucasian (Czech) normotensive (normotension was confirmed by 24-h ambulatory blood pressure monitoring) and hypertensive subjects of the age of 45-55 years were compared in three ET-1 gene (6p21.3) polymorphisms CA/CT dinucleotide repeat in Z-area, I/D (-4A/-3A) polymorphism in the promoter and Taq1 (G8002A) polymorphism in the intron 4 detected by PCR methods.The allelic length of CA/CT dinucleotide repeat polymorphism was significantly higher in hypertensive subjects (P=0.032). Allelic concurrence of I/D promoter polymorphism and Taq1 polymorphism was significantly different (P=0.008) in hypertensive vs.normotensive women (not in men). Linkage disequilibria between CA/CT and Taq polymorphisms were found both in hypertensive (P=0.008) and normotensive (P=0.02) subjects. Complex interaction among alleles inside the gene coding for ET-1 gene could participate in pathogenesis of essential hypertension. (en)
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Title
| - An association of three polymorphisms in the gene coding for endothelin-1 (ET-1) in essential hypertension
- An association of three polymorphisms in the gene coding for endothelin-1 (ET-1) in essential hypertension (en)
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skos:prefLabel
| - An association of three polymorphisms in the gene coding for endothelin-1 (ET-1) in essential hypertension
- An association of three polymorphisms in the gene coding for endothelin-1 (ET-1) in essential hypertension (en)
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skos:notation
| - RIV/00216224:14110/00:00002557!RIV/2002/GA0/141102/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA306/96/0099), P(VS96097), Z(MSM 141100002)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/00:00002557
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - An association of three polymorphisms in the gene coding for endothelin-1 (ET-1) in essential hypertension (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...ocetUcastnikuAkce
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http://linked.open...nichUcastnikuAkce
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Souček, Miroslav
- Vašků, Anna
- Mužík, Jan
- Tschöplová, Svatava
- Vácha, Jiří
- Izakovičová-Hollá, Lýdie
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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