About: Intracranial Pressure Declines During Cardiopulmonary Resuscitation in Animal Model

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Intracranial hypertension represents a significant risk factor of poor neurological outcome in critically ill, specifically those with craniotrauma. Methods: In a porcine model of cardiac arrest (CA) the dynamics of intracranial pressure (ICP) was studied. Threeminutes of untreated CA were followed by 5-minutes of cardiopulmonary resuscitation (CPR) with chest compressions and mechanical ventilation. No other interventions were allowed since out-of-hospital resuscitation was simulated. Throughout the protocol the ICP, arterial and venous pressures and carotid blood flow were continuously recorded. Results: During cardiac arrest ICP increased to 27 +/- 4.8 mmHg, i.e. hypertensive values. Mechanical chest compressions resulted in a transient ICP increase followed by a steady decline at approximately 2.25 mmHg/min. By five minutes of CPR intracranial pressure reached prearrest values despite significant elevation of central venous pressure (39 mmHg) and gradual decrease of arterial pressure and flow. We hypothesize that cerebral autoregulation is capable of maintaining ICP even during failing circulation. Intracranial hypertension represents a significant risk factor of poor neurological outcome in critically ill, specifically those with craniotrauma. Methods: In a porcine model of cardiac arrest (CA) the dynamics of intracranial pressure (ICP) was studied. Threeminutes of untreated CA were followed by 5-minutes of cardiopulmonary resuscitation (CPR) with chest compressions and mechanical ventilation. No other interventions were allowed since out-of-hospital resuscitation was simulated. Throughout the protocol the ICP, arterial and venous pressures and carotid blood flow were continuously recorded. Results: During cardiac arrest ICP increased to 27 +/- 4.8 mmHg, i.e. hypertensive values. Mechanical chest compressions resulted in a transient ICP increase followed by a steady decline at approximately 2.25 mmHg/min. By five minutes of CPR intracranial pressure reached prearrest values despite significant elevation of central venous pressure (39 mmHg) and gradual decrease of arterial pressure and flow. We hypothesize that cerebral autoregulation is capable of maintaining ICP even during failing circulation. (en)
Title	Intracranial Pressure Declines During Cardiopulmonary Resuscitation in Animal Model Intracranial Pressure Declines During Cardiopulmonary Resuscitation in Animal Model (en)
skos:prefLabel	Intracranial Pressure Declines During Cardiopulmonary Resuscitation in Animal Model Intracranial Pressure Declines During Cardiopulmonary Resuscitation in Animal Model (en)
skos:notation	RIV/00216208:11510/14:10287685!RIV15-MSM-11510___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(GAP407/10/1624), S
http://linked.open...iv/cisloPeriodika	S1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Mayer, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Fakulta tělesné výchovy a sportu
http://linked.open...dnocenehoVysledku	22597
http://linked.open...ai/riv/idVysledku	RIV/00216208:11510/14:10287685
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Model.; Animal; Resuscitation; Cardiopulmonary; During; Declines; Pressure; Intracranial (en)
http://linked.open.../riv/klicoveSlovo	Animal Cardiopulmonary Declines Model. Pressure Intracranial During Resuscitation
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[88CF8328DF53]
http://linked.open...i/riv/nazevZdroje	Biomedizinische Technik. Biomedical engineering
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Identification of limit effects of hypokinetic enviromental stress on human sensomotoric reactions reliability
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	59
http://linked.open...iv/tvurceVysledku	Mayer, Martin Mlček, Mikuláš Hrachovina, Matěj
http://linked.open...ain/vavai/riv/wos	000350405700430
issn	0013-5585
number of pages	3 (xsd:int)
http://localhost/t...ganizacniJednotka	11510

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