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  • Creatine (CR), is recommended for application as food supplement. It is supposed that human organism uses it for formation of CR phosphate as source of energy. In our short-term experiments we have observed changes in the metabolism of two-carbon (2C) units and of thiolic substances 4 to 6 hours after CR supplementation. The level of thiodiglycolic acid (TDGA) in urine increased rapidly and then decreased again to the original level. The level of TDGA in urine is a marker of disturbance in metabolic pathways of 2C units and of thiolic compounds. Our long-term CR supplementation, revealed that the biochemical pathways, affected by CR application included intrinsic participation of vitamin B12 and folates. The levels of those two vitamins changed in a mutually reverse way. The men under study can be divided into 4 different groups according to changes of CR levels found in urine, and of levels of folates and vitamin B12, determined in blood before and after CR administration.
  • Creatine (CR), is recommended for application as food supplement. It is supposed that human organism uses it for formation of CR phosphate as source of energy. In our short-term experiments we have observed changes in the metabolism of two-carbon (2C) units and of thiolic substances 4 to 6 hours after CR supplementation. The level of thiodiglycolic acid (TDGA) in urine increased rapidly and then decreased again to the original level. The level of TDGA in urine is a marker of disturbance in metabolic pathways of 2C units and of thiolic compounds. Our long-term CR supplementation, revealed that the biochemical pathways, affected by CR application included intrinsic participation of vitamin B12 and folates. The levels of those two vitamins changed in a mutually reverse way. The men under study can be divided into 4 different groups according to changes of CR levels found in urine, and of levels of folates and vitamin B12, determined in blood before and after CR administration. (en)
Title
  • Effect of Creatine Applied as Food Supplement on Human Metabolism
  • Effect of Creatine Applied as Food Supplement on Human Metabolism (en)
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  • Effect of Creatine Applied as Food Supplement on Human Metabolism
  • Effect of Creatine Applied as Food Supplement on Human Metabolism (en)
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  • RIV/00216208:11510/10:10071295!RIV11-MSM-11510___
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  • RIV/00216208:11510/10:10071295
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  • thiodiglycolic acid (TDGA); homocysteine; human metabolism; vitamin B12; folate; supplementation; creatine (en)
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  • Navrátil, Tomáš
  • Kohlíková, Eva
  • Petr, Miroslav
  • Přistoupilová, Kamila
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  • 11510
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