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| rdfs:seeAlso
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| Description
| - Haem oxygenase 1 (HO-1) plays a pivotal role in metabolic stress protecting cells in dependence on reactive oxygen species. This study investigated a potential gene environment interaction between the (GT)n repeat HO1 polymorphism and the stress perception in patients with eating disorder and in controls. Stress perception and (GT)n polymorphism were measured in 127 patients with eating disorders and in 78 healthy controls using Stress and Coping Inventory and genotyping. Based on the inventory, overall, specific and weighted stress scores were defined. Clinical stress score was generated according to the patient's history and interviews. According to our hypothesis, 1) all stress scores describing subjective stress perception were significantly higher in patients compared to controls (P LESS-THAN OR EQUAL TO 0.001; P LESS-THAN OR EQUAL TO 0.002; P LESS-THAN OR EQUAL TO 0.001), 2) the L/L genotype of GT promoter repeats (L < 25 GT repeats, S < 25 GT repeats) in the patients was associated with higher overall (P LESS-THAN OR EQUAL TO 0.001), specific (P LESS-THAN OR EQUAL TO 0.010) and weighted stress score (P LESS-THAN OR EQUAL TO 0.005) compared to the L/S variant, and 3) Pearson's correlation of clinical versus objective stress scores showed not very tight relationship (0.198; 0.287; 0.224, respectively). We assume potential risk of the L allele of HO1 promoter polymorphism for the stress response and contribution of the subjective stress perception together with the L/L genotype to the development of eating disorder. Decreased HO1 expression in the presence of L/L genotype plus more intensive stress perception in the patients can lead to secondary stress, with increasing severity of the symptoms and aggravation of the disease.
- Haem oxygenase 1 (HO-1) plays a pivotal role in metabolic stress protecting cells in dependence on reactive oxygen species. This study investigated a potential gene environment interaction between the (GT)n repeat HO1 polymorphism and the stress perception in patients with eating disorder and in controls. Stress perception and (GT)n polymorphism were measured in 127 patients with eating disorders and in 78 healthy controls using Stress and Coping Inventory and genotyping. Based on the inventory, overall, specific and weighted stress scores were defined. Clinical stress score was generated according to the patient's history and interviews. According to our hypothesis, 1) all stress scores describing subjective stress perception were significantly higher in patients compared to controls (P LESS-THAN OR EQUAL TO 0.001; P LESS-THAN OR EQUAL TO 0.002; P LESS-THAN OR EQUAL TO 0.001), 2) the L/L genotype of GT promoter repeats (L < 25 GT repeats, S < 25 GT repeats) in the patients was associated with higher overall (P LESS-THAN OR EQUAL TO 0.001), specific (P LESS-THAN OR EQUAL TO 0.010) and weighted stress score (P LESS-THAN OR EQUAL TO 0.005) compared to the L/S variant, and 3) Pearson's correlation of clinical versus objective stress scores showed not very tight relationship (0.198; 0.287; 0.224, respectively). We assume potential risk of the L allele of HO1 promoter polymorphism for the stress response and contribution of the subjective stress perception together with the L/L genotype to the development of eating disorder. Decreased HO1 expression in the presence of L/L genotype plus more intensive stress perception in the patients can lead to secondary stress, with increasing severity of the symptoms and aggravation of the disease. (en)
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| Title
| - Stress Perception and (GT)n Repeat Polymorphism in Haem Oxygenase 1 Promoter Are Both Risk Factors in Development of Eating Disorders
- Stress Perception and (GT)n Repeat Polymorphism in Haem Oxygenase 1 Promoter Are Both Risk Factors in Development of Eating Disorders (en)
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| skos:prefLabel
| - Stress Perception and (GT)n Repeat Polymorphism in Haem Oxygenase 1 Promoter Are Both Risk Factors in Development of Eating Disorders
- Stress Perception and (GT)n Repeat Polymorphism in Haem Oxygenase 1 Promoter Are Both Risk Factors in Development of Eating Disorders (en)
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| skos:notation
| - RIV/00216208:11410/13:10193340!RIV15-MSM-11410___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - I, P(NT14094), Z(MSM0021620849)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11410/13:10193340
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - development; disorders; eating; factors; risk; both; are; gene; HO-1; polymorphism; repeat; GTn; perception; Stress (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Papežová, Hana
- Králík, Lubomír
- Martásek, Pavel
- Chvál, Martin
- Kaminská, Deborah
- Šlachtová, Lenka
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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