About: Sphingolipid levels crucially modulate lateral microdomain organization of plasma membrane in living yeast     Goto   Sponge   NotDistinct   Permalink

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  • We report sphingolipid-related reorganization of gel-like microdomains in the plasma membrane of living Saccharomyces cerevisiae using trans-Parinaric acid (t-PnA) and 1,6-diphenyl-1,3,5-hexatriene (DPH). Compared to control, the gel-like domains were significantly reduced in the membrane of a sphingolipid-deficient lcb1-100 mutant. The same reduction resulted from sphingolipid depletion by myriocin. The phenotype could be reverted when a myriocin-induced block in sphingolipid biosynthesis was bypassed by exogenous dihydrosphingosine. Lipid order of less-ordered membrane regions decreased with sphingolipid depletion as well, as documented by DPH fluorescence anisotropy. The data indicate that organization of lateral microdomains is an essential physiological role of these structural lipids. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
  • We report sphingolipid-related reorganization of gel-like microdomains in the plasma membrane of living Saccharomyces cerevisiae using trans-Parinaric acid (t-PnA) and 1,6-diphenyl-1,3,5-hexatriene (DPH). Compared to control, the gel-like domains were significantly reduced in the membrane of a sphingolipid-deficient lcb1-100 mutant. The same reduction resulted from sphingolipid depletion by myriocin. The phenotype could be reverted when a myriocin-induced block in sphingolipid biosynthesis was bypassed by exogenous dihydrosphingosine. Lipid order of less-ordered membrane regions decreased with sphingolipid depletion as well, as documented by DPH fluorescence anisotropy. The data indicate that organization of lateral microdomains is an essential physiological role of these structural lipids. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. (en)
Title
  • Sphingolipid levels crucially modulate lateral microdomain organization of plasma membrane in living yeast
  • Sphingolipid levels crucially modulate lateral microdomain organization of plasma membrane in living yeast (en)
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  • Sphingolipid levels crucially modulate lateral microdomain organization of plasma membrane in living yeast
  • Sphingolipid levels crucially modulate lateral microdomain organization of plasma membrane in living yeast (en)
skos:notation
  • RIV/00216208:11320/14:10283120!RIV15-MSM-11320___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(GAP205/12/0720)
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 46626
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  • RIV/00216208:11320/14:10283120
http://linked.open...riv/jazykVysledku
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  • Time-resolved fluorescence; Fluorescence anisotropy; Fluidity; Lipid order; Membrane microdomain (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [A17134E641C7]
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  • FEBS Letters
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http://linked.open...v/svazekPeriodika
  • 588
http://linked.open...iv/tvurceVysledku
  • Heřman, Petr
  • Večeř, Jaroslav
  • Malinsky, Jan
  • Vesela, Petra
http://linked.open...ain/vavai/riv/wos
  • 000329976800010
issn
  • 0014-5793
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.febslet.2013.11.038
http://localhost/t...ganizacniJednotka
  • 11320
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