About: Magnesium effect on premelting transitions in nucleic acids: DNA duplex and RNA hairpin models

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About: Magnesium effect on premelting transitions in nucleic acids: DNA duplex and RNA hairpin models Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0022286010009786
Description	The effect of magnesium ions on the conformational changes in the temperature region below the melting transition (premelting transitions) of a DNA duplex and an RNA hairpin was studied by difference Raman spectroscopy. The chosen model systems were the polynucleotide poly(dA)-poly(dT) duplex and the apical hairpin of the trans-activation response (TAR) element of HIV-1. Magnesium effect was displayed by differences of Raman spectra measured at various temperatures with and without magnesium ions. Our results have revealed that magnesium ions influence measurably the premelting transitions in both cases; the extent of the effect and its character is though quite different. In the case of the B'- B premelting transition of the polynucleotide poly(dA)-poly(dT) duplex, magnesium binds to the minor groove of the B but not of the B0 form and acts again the rearrangement in the vicinity of the thymidine keto-groups. On the other hand, the magnesium effect on the TAR hairpin premelting consists in a weak support of the premelting structural change via more effective electrostatic shielding. The effect of magnesium ions on the conformational changes in the temperature region below the melting transition (premelting transitions) of a DNA duplex and an RNA hairpin was studied by difference Raman spectroscopy. The chosen model systems were the polynucleotide poly(dA)-poly(dT) duplex and the apical hairpin of the trans-activation response (TAR) element of HIV-1. Magnesium effect was displayed by differences of Raman spectra measured at various temperatures with and without magnesium ions. Our results have revealed that magnesium ions influence measurably the premelting transitions in both cases; the extent of the effect and its character is though quite different. In the case of the B'- B premelting transition of the polynucleotide poly(dA)-poly(dT) duplex, magnesium binds to the minor groove of the B but not of the B0 form and acts again the rearrangement in the vicinity of the thymidine keto-groups. On the other hand, the magnesium effect on the TAR hairpin premelting consists in a weak support of the premelting structural change via more effective electrostatic shielding. (en)
Title	Magnesium effect on premelting transitions in nucleic acids: DNA duplex and RNA hairpin models Magnesium effect on premelting transitions in nucleic acids: DNA duplex and RNA hairpin models (en)
skos:prefLabel	Magnesium effect on premelting transitions in nucleic acids: DNA duplex and RNA hairpin models Magnesium effect on premelting transitions in nucleic acids: DNA duplex and RNA hairpin models (en)
skos:notation	RIV/00216208:11320/11:10108119!RIV12-GA0-11320___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA202/09/0193), P(GD202/09/H041), S, Z(MSM0021620835)
http://linked.open...iv/cisloPeriodika	1-3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Štěpánek, Josef Espinoza Herrera, Shirly Josefina Ottová, Pavla
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Matematicko-fyzikální fakulta
http://linked.open...dnocenehoVysledku	210198
http://linked.open...ai/riv/idVysledku	RIV/00216208:11320/11:10108119
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Magnesium ions; Poly(dA)-poly(dT); TAR; RNA hairpin; DNA duplex; Raman spectroscopy (en)
http://linked.open.../riv/klicoveSlovo	DNA duplex Magnesium ions Poly(dA)-poly(dT) RNA hairpin TAR Raman spectroscopy
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[CE3478F540C5]
http://linked.open...i/riv/nazevZdroje	Journal of Molecular Structure
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Physics of nanostructures Formation and dynamics of nucleic acid motifs involved in regulation of gene expression
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	993
http://linked.open...iv/tvurceVysledku	Štěpánek, Josef Espinoza Herrera, Shirly Josefina Ottová, Pavla
http://linked.open...ain/vavai/riv/wos	000291066000052
http://linked.open...n/vavai/riv/zamer	Fyzika molekulárních, makromolekulárních a biologických systémů
issn	0022-2860
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.molstruc.2010.12.025
http://localhost/t...ganizacniJednotka	11320

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