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Description
  • We demonstrate the advantage of the simultaneous multicurve nonlinear least-squares analysis over that of the conventional single-curve analysis. Fitting results are subjected to thorough Monte Carlo analysis for rigorous assessment of confidence intervals and parameter correlations. The comparison is performed on a practical example of simulated steady-state reaction kinetics complemented with isothermal calorimetry (ITC) data resembling allosteric behavior of rabbit muscle pyruvate kinase (RMPK). Global analysis improves accuracy and confidence limits of model parameters. Cross-correlation between parameters is also reduced with accompanying enhancement of the model-testing power. This becomes especially important for validation of models with %22difficult%22 highly cross-correlated parameters. We show how proper experimental design and critical evaluation of data can improve the chance of differentiating models.
  • We demonstrate the advantage of the simultaneous multicurve nonlinear least-squares analysis over that of the conventional single-curve analysis. Fitting results are subjected to thorough Monte Carlo analysis for rigorous assessment of confidence intervals and parameter correlations. The comparison is performed on a practical example of simulated steady-state reaction kinetics complemented with isothermal calorimetry (ITC) data resembling allosteric behavior of rabbit muscle pyruvate kinase (RMPK). Global analysis improves accuracy and confidence limits of model parameters. Cross-correlation between parameters is also reduced with accompanying enhancement of the model-testing power. This becomes especially important for validation of models with %22difficult%22 highly cross-correlated parameters. We show how proper experimental design and critical evaluation of data can improve the chance of differentiating models. (en)
Title
  • The advantage of global fitting of data involving complex linked reactions
  • The advantage of global fitting of data involving complex linked reactions (en)
skos:prefLabel
  • The advantage of global fitting of data involving complex linked reactions
  • The advantage of global fitting of data involving complex linked reactions (en)
skos:notation
  • RIV/00216208:11320/11:10105562!RIV12-MSM-11320___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM0021620835)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 184767
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11320/11:10105562
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Monte Carlo; linked reactions; data analysis; global fitting (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [81D7E55DC2BD]
http://linked.open...i/riv/mistoVydani
  • New York
http://linked.open...vEdiceCisloSvazku
  • 796
http://linked.open...i/riv/nazevZdroje
  • Allostery: Methods and Protocols
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...v/pocetStranKnihy
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Heřman, Petr
  • Lee, J., C.
http://linked.open...n/vavai/riv/zamer
number of pages
http://bibframe.org/vocab/doi
  • 10.1007/978-1-61779-334-9_22
http://purl.org/ne...btex#hasPublisher
  • Humana Press
https://schema.org/isbn
  • 978-1-61779-333-2
http://localhost/t...ganizacniJednotka
  • 11320
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